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001-es BibID:	BIBFORM115756
035-os BibID:	(cikkazonosító)706 (Scopus)85175147047
Első szerző:	Tarban, Nastaran (molekuláris biológus)
Cím:	Loss of adenosine A3 receptors accelerates skeletal muscle regeneration in mice following cardiotoxin-induced injury / Nastaran Tarban, Albert Bálint Papp, Dávid Deák, Péter Szentesi, Hajnalka Halász, Andreas Patsalos, László Csernoch, Zsolt Sarang, Zsuzsa Szondy
Dátum:	2023
ISSN:	2041-4889
Megjegyzések:	Skeletal muscle regeneration is a complex process orchestrated by multiple interacting steps. An increasing number of reports indicate that inflammatory responses play a central role in linking initial muscle injury responses to timely muscle regeneration following injury. The nucleoside adenosine has been known for a long time as an endogenously produced anti-inflammatory molecule that is generated in high amounts during tissue injury. It mediates its physiological effects via four types of adenosine receptors. From these, adenosine A3 receptors (A3Rs) are not expressed by the skeletal muscle but are present on the surface of various inflammatory cells. In the present paper, the effect of the loss of A3Rs was investigated on the regeneration of the tibialis anterior (TA) muscle in mice following cardiotoxin-induced injury. Here we report that regeneration of the skeletal muscle from A3R?/? mice is characterized by a stronger initial inflammatory response resulting in a larger number of transmigrating inflammatory cells to the injury site, faster clearance of cell debris, enhanced proliferation and faster differentiation of the satellite cells (the muscle stem cells), and increased fusion of the generated myoblasts. This leads to accelerated skeletal muscle tissue repair and the formation of larger myofibers. Though the infiltrating immune cells expressed A3Rs and showed an increased inflammatory profile in the injured A3R?/? muscles, bone marrow transplantation experiments revealed that the increased response of the tissue-resident cells to tissue injury is responsible for the observed phenomenon. Altogether our data indicate that A3Rs are negative regulators of injury-related regenerative inflammation and consequently also that of the muscle fiber growth in the TA muscle. Thus, inhibiting A3Rs might have a therapeutic value during skeletal muscle regeneration following injury.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Adaptive immunity Cell signalling Trauma
Megjelenés:	Cell Death & Disease. - 14 : 10 (2023), p. 706. -
További szerzők:	Papp Albert Bálint Deák Dávid Szentesi Péter (1967-) (élettanász) Halász Hajnalka Emese (1994-) (Molekuláris biológus) Patsalos, Andreas Csernoch László (1961-) (élettanász) Sarang Zsolt (1976-) (mikrobiológus) Szondy Zsuzsanna (1959-) (molekuláris sejtbiológus, biokémikus)
Pályázati támogatás:	NKFIH - K138162 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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