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001-es BibID:	BIBFORM115964
035-os BibID:	(Scopus)85121545931 (WoS)000732547800002 (cikkazonosító)1418
Első szerző:	Orta, Alberto H.
Cím:	Rats exhibit age-related mosaic loss of chromosome Y / Alberto H. Orta, Stephen J. Bush, Mariana Gutiérrez-Mariscal, Susana Castro-Obregón, Lorraine Jaimes-Hoy, Ricardo Grande5, Gloria Vázquez, Elisa Gorostieta-Salas, Mónica Martínez-Pacheco, Karina Díaz-Barba, Paola Cornejo-Páramo, Alejandro Sanchez-Flores, Tamas Székely, Araxi O. Urrutia, Diego Cortez
Dátum:	2021
ISSN:	2399-3642
Megjegyzések:	Mosaic loss of the Y chromosome (LOY) is the most frequent chromosomal aberration in aging men and is strongly correlated with mortality and disease. To date, studies of LOY have only been performed in humans, and so it is unclear whether LOY is a natural consequence of our relatively long lifespan or due to exposure to human-specific external stressors. Here, we explored whether LOY could be detected in rats. We applied a locus-specific PCR and target sequencing approach that we used as a proxy to estimate LOY in 339 samples covering eleven tissues from young and old individuals. We detected LOY in four tissues of older rats. To confirm the results from the PCR screening, we re-sequenced 60 full genomes from old rats, which revealed that the Y chromosome is the sole chromosome with low copy numbers. Finally, our results suggest that LOY is associated with other structural aberrations on the Y chromosome and possibly linked to the mosaic loss of the X chromosome. This is the first report, to our knowledge, demonstrating that the patterns of LOY observed in aging men are also present in a rodent, and conclude that LOY may be a natural process in placental mammals.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Communications Biology. - 4 : 1 (2021), p. 1-8. -
További szerzők:	Bush, Stephen J. Gutiérrez-Mariscal, Mariana Castro-Obregón, Susana Jaimes-Hoy, Lorraine Grande, Ricardo Vázquez, Gloria Gorostieta-Salas, Elisa Martínez-Pacheco, Mónica Díaz-Barba, Karina Cornejo-Páramo, Paola Sanchez-Flores, Alejandro Székely Tamás (1959-) (biológus) Urrutia, Araxi Cortez, Diego
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