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001-es BibID:	BIBFORM116649
035-os BibID:	(cikkazonosító)1280240 (WoS)001104300200001 (Scopus)85177446393
Első szerző:	Hakamifard, Atousa
Cím:	Efficacy of adjunctive topical liposomal clarithromycin on systemic Glucantime in Old World cutaneous leishmaniasis : a pilot clinical study / Atousa Hakamifard, Reza Radmehr, Fatemeh Sokhanvari, Fatemeh Sherkat, Amirali Hariri, Jaleh Varshosaz, Zabihollah Shahmoradi, Awat Feizi, Bahareh Abtahi-Naeini, Mahsa Pourmahdi-Boroujeni
Dátum:	2023
ISSN:	1663-9812
Megjegyzések:	Aim: This study aimed to investigate the effects of topical liposomal clarithromycin in combination with meglumine antimoniate (Glucantime (R)) on cutaneous leishmaniasis (CL) lesions.Methods: This pilot, randomized, double-blinded clinical trial was conducted on patients with CL lesions. Patients were randomly assigned to two groups: the first group received liposomal clarithromycin in combination with Glucantime for 28 days, while the second group received Glucantime and a placebo. Afterward, patients were followed up at 1.5, 3, and 6 months after treatment initiation and were evaluated for recovery time, induration, and size of the lesions.Results: Sixty patients with CL lesions were divided into two separate groups with 30 members each and were examined. Within-group analysis revealed that recovery time in the clarithromycin group was 26.65 +/- 5.12 days, while in the placebo group, it was 32.84 +/- 24.43, which was statistically insignificant (p = 0.18). Lesion size comparison in the first and last follow-ups reduced in both groups: 7.73 +/- 4.31 to 0.48 +/- 0.50 in the clarithromycin group (p = 0.006) and 5.47 +/- 5.83 to 0.76 +/- 0.88 in the placebo group (p = 0.03). Moreover, the size of lesions in the intervention group was significantly reduced compared to that in the placebo group (p = 0.02). Recognizable induration reduction was observed in the clarithromycin group (2.60 +/- 0.77 to 1.0 +/- 0.00). No adverse effects attributable to clarithromycin were reported.Conclusion: The administration of liposomal clarithromycin in combination with systemic Glucantime had a significant beneficial effect on reducing lesion size in leishmaniasis. Further studies on larger populations are recommended.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk clarithromycin cutaneous leishmaniasis Glucantime leishmaniasis liposomal clarithromycin
Megjelenés:	Frontiers in Pharmacology. - 14 (2023), p. 1-8. -
További szerzők:	Radmehr, Reza Sokhanvari, Fatemeh Sherkat, Fatemeh Hariri, Amirali Varshosaz, Jaleh Shahmoradi, Zabihollah Feizi, Awat Abtahi-Naeini, Bahareh Pourmahdi-Boroujeni, Mahsa
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