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001-es BibID:	BIBFORM116680
035-os BibID:	(scopus)85170035800 (wos)001065103600003
Első szerző:	Pandics Tamás
Cím:	Exposome and unhealthy aging : environmental drivers from air pollution to occupational exposures / Pandics Tamas, Major David, Fazekas-Pongor Vince, Szarvas Zsofia, Peterfi Anna, Mukli Peter, Gulej Rafal, Ungvari Anna, Fekete Monika, Tompa Anna, Tarantini Stefano, Yabluchanskiy Andriy, Conley Shannon, Csiszar Anna, Tabak Adam G., Benyo Zoltan, Adany Roza, Ungvari Zoltan
Dátum:	2023
ISSN:	2509-2715 2509-2723
Megjegyzések:	The aging population worldwide is facing a significant increase in age-related non-communicable diseases, including cardiovascular and brain pathologies. This comprehensive review paper delves into the impact of the exposome, which encompasses the totality of environmental exposures, on unhealthy aging. It explores how environmental factors contribute to the acceleration of aging processes, increase biological age, and facilitate the development and progression of a wide range of age-associated diseases. The impact of environmental factors on cognitive health and the development of chronic age-related diseases affecting the cardiovascular system and central nervous system is discussed, with a specific focus on Alzheimer's disease, Parkinson's disease, stroke, small vessel disease, and vascular cognitive impairment (VCI). Aging is a major risk factor for these diseases. Their pathogenesis involves cellular and molecular mechanisms of aging such as increased oxidative stress, impaired mitochondrial function, DNA damage, and inflammation and is influenced by environmental factors. Environmental toxicants, including ambient particulate matter, pesticides, heavy metals, and organic solvents, have been identified as significant contributors to cardiovascular and brain aging disorders. These toxicants can inflict both macro- and microvascular damage and many of them can also cross the blood?brain barrier, inducing neurotoxic effects, neuroinflammation, and neuronal dysfunction. In conclusion, environmental factors play a critical role in modulating cardiovascular and brain aging. A deeper understanding of how environmental toxicants exacerbate aging processes and contribute to the pathogenesis of neurodegenerative diseases, VCI, and dementia is crucial for the development of preventive strategies and interventions to promote cardiovascular, cerebrovascular, and brain health. By mitigating exposure to harmful environmental factors and promoting healthy aging, we can strive to reduce the burden of age-related cardiovascular and brain pathologies in the aging population. ? 2023, The Author(s).
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Accelerated aging Aging Biological age Environmental pollution Exposome Toxicology
Megjelenés:	GeroScience. - 45 : 6 (2023), p. 3381-3408. -
További szerzők:	Major Dávid Fazekas-Pongor Vince Szarvas Zsófia Péterfi Anna Mukli Péter Gulej, Rafal Ungvári Anna Fekete Mónika Tompa Anna Tarantini, Stefano Yabluchanskiy, Andriy Conley, Shannon M. Csiszár Anna Tabák Ádám G. Benyó Zoltán Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Ungvári Zoltán
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