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001-es BibID:	BIBFORM117160
035-os BibID:	(WoS)001109979200001
Első szerző:	Kovács Erzsébet (belgyógyász)
Cím:	Clinical investigation of hereditary and acquired thrombophilic factors in patients with venous and arterial thromboembolism / Erzsebet Kovács, Zsuzsanna Bereczky, Adrienne Kerényi, Renáta Laczik, Valéria Nagy, Dávid Ágoston Kovács, Sándor Kovács, György Pfliegler
Dátum:	2023
ISSN:	1178-7074
Megjegyzések:	Background: The clinical relevance of thrombophilic laboratory factors, especially the "mild" ones, and the need for their screening is not generally recommended in venous (VTE) and/or arterial (ATE) thromboembolism. Methods: Our aim was to investigate possible associations between comorbidities and 16 inherited/acquired "severe" and "mild" laboratory thrombophilic factors (detailed in introduction) in patients (n=348) with VTE/ATE without a serious trigger (high-risk surgical intervention, active cancer and/or chemo-radiotherapy). Cases with VTE/ATE were enrolled when the thrombotic event occurred under the age of 40, in case of positive family history, recurrent thromboembolism, idiopathic event or unusual location. Patients without a detailed thrombophilia screening or who suffered from both ATE/VTE were excluded to find potential distinct thrombosis type specific thrombophilic risks. The possible role of "mild" factor accumulation was also investigated in VTE (n=266). Results: Elevation of factor VIII clotting activity was associated with VTE rather than ATE. Varicose veins together with postthrombotic syndrome were strongly related to several "mild" factors. Besides "severe" we found that the "mild" thrombophilic factors were also strongly associated with VTE/ATE. Comorbidities/conditions such as diabetes and smoking were generally associated with hyperlipidemia; moreover, both had a correlation with lipoprotein (a) in VTE. We also revealed an important contribution of "mild" factors in increasing trends of several types and localizations of VTE. Conclusion: In summary, besides the "severe" thrombophilic factors, the "mild" ones also seem to play a non-negligible role in the manifestation of thrombosis, especially in combination. Therefore, an extended screening might be useful in the personalized recommendation of antithrombotic prophylaxis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk thrombosis hemostasis thrombophilia venous thromboembolism arterial thromboembolism
Megjelenés:	International Journal of General Medicine. - 16 (2023), p. 5425-5437. -
További szerzők:	Bereczky Zsuzsanna (1974-) (orvosi laboratóriumi diagnosztika szakorvos) Kerényi Adrienne (1970-) (laboratóriumi szakorvos) Laczik Renáta (1982-) (orvos) Nagy Valéria (1962-) (szemész) Kovács Dávid Ágoston (1982-) (sebész) Kovács Sándor (1978-) (matematika tanár) Pfliegler György (1949-) (belgyógyász, hematológus, labor szakorvos)
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