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001-es BibID:	BIBFORM117559
035-os BibID:	(WoS)001151548500001 (Scopus)85183097013
Első szerző:	Bácskay Ildikó (gyógyszerész, gyógyszertechnológus)
Cím:	Formulation and Evaluation of Insulin-Loaded Sodium-Alginate Microparticles for Oral Administration / Ildikó Bácskay, Boglárka Papp, Péter Pártos, István Budai, Ágota Pető, Pálma Fehér, Zoltán Ujhelyi, Dóra Kósa
Dátum:	2024
ISSN:	1999-4923
Megjegyzések:	The development of oral insulin drug delivery systems is still an ongoing challenge for pharmaceutical technology researchers, as the formulation process has to overcome a number of obstacles due to the adverse characteristics of peptides. The aim of this study was to formulate different sodium-alginate microparticles as a possible method for oral insulin administration. In our previous studies, the method has been successfully optimized using a small model peptide. The incorporation of insulin into alginate carriers containing nonionic surfactants has not been described yet. In order to enhance the absorption of insulin through biological barriers, Labrasol ALF and Labrafil M 2125 CS were selected as permeation-enhancing excipients. They were applied at a concentration of 0.10% (v/v%), along with various combinations of the two, to increase oral bioavailability. Encapsulation efficiency showed sufficient drug incorporation, as it resulted in over 80% in each composition. In vitro dissolution and enzymatic stability test results proved that, as a pH-responsive polymer, alginate bead swelling and drug release occur at higher pH, thus protecting insulin against the harsh environment of the gastrointestinal tract. The remaining insulin content was 66% due to SIF degradation after 120 min. Permeability experiments revealed the impact of permeation enhancers and natural polymers on drug absorption, as they enhanced drug transport significantly through Caco-2 cells in the case of alginate microparticle formulations, as opposed to the control insulin solution. These results suggest that these formulations are able to improve the oral bioavailability of insulin.
Tárgyszavak:	Műszaki tudományok Anyagtudományok és technológiák idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk microbead oral bioavailability absorption enhancement Labrasol ALF Labrafil M 2125 CS Caco-2 cells
Megjelenés:	Pharmaceutics. - 16 : 1 (2024), p. 1-16. -
További szerzők:	Papp Boglárka (1997-) (Gyógyszerész) Pártos Péter (gyógyszerész) Budai István (1977-) (folyamatmérnök) Pető Ágota (1994-) (gyógyszerész) Fehér Pálma (1976-) (gyógyszerész) Ujhelyi Zoltán (1984-) (gyógyszerész) Kósa Dóra (1994-) (gyógyszerész)
Pályázati támogatás:	ÚNKP-22-4-I Egyéb TKP2021-EGA-19 Egyéb GINOP-2.3.1-20-2020-00004 GINOP GINOP-2.3.4-15-2016-00002 GINOP
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