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001-es BibID:	BIBFORM117681
035-os BibID:	(WoS)001138525600001 (Scopus)85181969555
Első szerző:	Szeőcs Dóra (PhD hallgató)
Cím:	Cell-free ascites from ovarian cancer patients induces Warburg metabolism and cell proliferation through TGFbeta-ERK signalling / Szeőcs D., Vida B., Petővári G., Póliska Sz., Janka E., Sipos A., Uray K., Sebestyén A., Krasznai Z., Bai P.
Dátum:	2024
ISSN:	2509-2715 2509-2723
Megjegyzések:	Ascites plays a key role in supporting the metastatic potential of ovarian cancer cells. Shear stress and carry-over of cancer cells by ascites flow support carcinogenesis and metastasis formation. In addition, soluble factors may participate in the procarcinogenic effects of ascites in ovarian cancer. This study aimed to determine the biological effects of cell-free ascites on carcinogenesis in ovarian cancer cells. Cell-free ascites from ovarian cancer patients (ASC) non-selectively induced cell proliferation in multiple models of ovarian cancer and untransformed primary human dermal fibroblasts. Furthermore, ASC induced a Warburg-type rearrangement of cellular metabolism in A2780 ovarian cancer cells characterized by increases in cellular oxygen consumption and glycolytic flux; increases in glycolytic flux were dominant. ASC induced mitochondrial uncoupling and fundamentally reduced fatty acid oxidation. Ascites-elicited effects were uniform among ascites specimens. ASC-elicited transcriptomic changes in A2780 ovarian cancer cells included induction of the TGF beta-ERK/MEK pathway, which plays a key role in inducing cell proliferation and oncometabolism. ASC-induced gene expression changes, as well as the overexpression of members of the TGF beta signaling system, were associated with poor survival in ovarian cancer patients. We provided evidence that the activation of the autocrine/paracrine of TGF beta signaling system may be present in bladder urothelial carcinoma and stomach adenocarcinoma. Database analysis suggests that the TGF beta system may feed forward bladder urothelial carcinoma and stomach adenocarcinoma. Soluble components of ASC support the progression of ovarian cancer. These results suggest that reducing ascites production may play an essential role in the treatment of ovarian cancer by inhibiting the progression and reducing the severity of the disease.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	GeroScience. - 46 : 4 (2024), p. 3581-3597. -
További szerzők:	Vida Beáta (1994-) (szülészet-nőgyógyászat) Petővári Gábor Póliska Szilárd (1978-) (biológus) Janka Eszter Anna (1989-) (bőrgyógyász, népegészségügyi szakember) Sipos Adrienn (1984-) (biológus, biotechnológus) Uray Karen (1964-) (biokémikus) Sebestyén Anna Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Bai Péter (1976-) (biokémikus)
Pályázati támogatás:	K142141 NKFIH FK128387 NKFIH FK146852 NKFIH TKP2021-EGA-19 NKFIH TKP2021-EGA-20 NKFIH POST-COVID2021-33 Egyéb NKM2022-30 Egyéb
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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