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001-es BibID:	BIBFORM118086
035-os BibID:	(Scopus)85182229542 (WoS)001147341400001
Első szerző:	Than Nándor Gábor (szülész-nőgyógyász)
Cím:	Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention / Nándor Gábor Than, Roberto Romero, Máté Posta, Dániel Györffy, Gábor Szalai, Simona W. Rossi, András Szilágyi, Petronella Hupuczi, Sándor Nagy, Olga Török, Adi L. Tarca, Offer Erez, Nándor Ács, Zoltán Papp
Dátum:	2024
ISSN:	0165-0378
Megjegyzések:	The prevention of pre-eclampsia is difficult due to the syndromic nature and multiple underlying mechanisms of this severe complication of pregnancy. The current clinical distinction between early- and late-onset disease, although clinically useful, does not reflect the true nature and complexity of the pathologic processes leading to pre-eclampsia. The current gaps in knowledge on the heterogeneous molecular pathways of this syndrome and the lack of adequate, specific diagnostic methods are major obstacles to early screening and tailored preventive strategies. The development of novel diagnostic tools for detecting the activation of the identified disease pathways would enable early, accurate screening and personalized preventive therapies. We implemented a holistic approach that includes the utilization of different proteomic profiling methods of maternal plasma samples collected from various ethnic populations and the application of systems biology analysis to plasma proteomic, maternal demographic, clinical characteristic, and placental histopathologic data. This approach enabled the identification of four molecular subclasses of pre-eclampsia in which distinct and shared disease mechanisms are activated. The current review summarizes the results and conclusions from these studies and the research and clinical implications of our findings.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Extracellular matrix-related pre-eclampsia Liquid biopsy Maternal anti-fetal rejection-type pre-eclampsia Metabolic pre-eclampsia Personalized medicine Placental pre-eclampsia Prenatal diagnosis Proteomics Screening
Megjelenés:	Journal Of Reproductive Immunology. - 161 (2024), p. 1-8. -
További szerzők:	Romero, Roberto Posta Máté Györffy Dániel Szalai Gábor Rossi, Simona Wilma Szilágyi András Hupuczi Petronella (anaesthesiológus) Nagy Sándor Török Olga (1956-) (szülész-nőgyógyász, humángenetikus) Tarca, Adi Laurentiu Erez, Offer Ács Nándor Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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