Találati lista | Tudóstér

001-es BibID:	BIBFORM118278
035-os BibID:	(Scopus)85183055620 (WoS)001148366700001
Első szerző:	Simanjuntak, Masriana Vivi
Cím:	Revealing Propolis Potential Activity on Inhibiting Estrogen Receptor and Heat Shock Protein 90 Overexpressed in Breast Cancer by Bioinformatics Approaches / Masriana Vivi Simanjuntak, Muhammad Miftah Jauhar, Putri Hawa Syaifie, Adzani Gaisani Arda, Etik Mardliyati, Wervyan Shalannanda, Beni Rio Hermanto, Isa Anshori
Dátum:	2024
ISSN:	1177-9322
Megjegyzések:	Breast cancer is the most commonly diagnosed cancer globally, with the highest incidence of breast cancer occurring in Asian countries including Indonesia. Among the types of breast cancer, the estrogen receptor (ER)-positive subtype which is prominent with estrogen receptor alpha (ER?) and heat shock protein 90 (HSP90) overexpression genes becomes the most prevalent than the others, approximately 75% of all breast cancer cases. ER? and HSP90 play a role in breast cancer activities including breast tumor growth, invasion, and metastasis mechanism. Propolis, a natural bee product, has been explored for its anticancer activity. However, there is lack of studies that evaluated the potential inhibitor from propolis compounds to the ER? and HSP90 proteins. Therefore, this article focuses on examining the correlation between ER? and HSP90's role in breast cancer and investigating the potential of 93 unique propolis compositions in inhibiting these genes in breast cancer using in silico approaches. This study revealed the positive correlation between ER? and HSP90 genes in breast cancer disease development. Furthermore, we also found novel potential bioactive compounds of propolis against breast cancer through binding with ER? and HSP90; they were 3',4',7-trihydroxyisoflavone and baicalein-7-O-?-D glucopyranoside, respectively. Further research on these compounds is needed to elucidate deeper mechanisms and activity in the real biological system to develop new breast cancer drug treatments.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Breast cancer estrogen receptor alpha heat shock protein 90 in silico propolis
Megjelenés:	Bioinformatics and Biology Insights. - 18 (2024), p. 1-19. -
További szerzők:	Jauhar, Muhammad Miftah Syaifie, Putri Hawa Arda, Adzani Gaisani Mardliyati, Etik Shalannanda, Wervyan Hermanto, Beni Rio Anshori, Isa
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: