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001-es BibID:	BIBFORM119614
035-os BibID:	(cikkazonosító)221 (Scopus)85189002423 (Wos)001193399100001
Első szerző:	Emri Tamás (biológus)
Cím:	The Oxidative Stress Response Highly Depends on Glucose and Iron Availability in Aspergillus fumigatus / Tamás Emri, Károly Antal, Kinga Varga, Barnabás Csaba Gila, István Pócsi
Dátum:	2024
ISSN:	2309-608X
Megjegyzések:	Pathogens have to cope with oxidative, iron- and carbon(glucose)-limitation stresses in the human body. To understand how combined iron-carbon limitation alters oxidative stress responses, Aspergillus fumigatus was cultured in glucose-peptone or peptone containing media supplemented or not with deferiprone as an iron chelator. Changes in the transcriptome in these cultures were recorded after H2O2 treatment. Responses to oxidative stress were highly dependent on the availability of glucose and iron. Out of the 16 stress responsive antioxidative enzyme genes, only the cat2 catalase-peroxidase gene was upregulated in more than two culturing conditions. The transcriptional responses observed in iron metabolism also varied substantially in these cultures. Only extracellular siderophore production appeared important regardless of culturing conditions in oxidative stress protection, while the enhanced synthesis of Fe-S cluster proteins seemed to be crucial for oxidative stress treated iron-limited and fast growing (glucose rich) cultures. Although pathogens and host cells live together in the same place, their culturing conditions (e.g., iron availability or occurrence of oxidative stress) can be different. Therefore, inhibition of a universally important biochemical process, like Fe-S cluster assembly, may selectively inhibit the pathogen growth in vivo and represent a potential target for antifungal therapy.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Aspergillus fumigatus carbon limitation deferiprone iron homeostasis oxidative stress RNA sequencing
Megjelenés:	Journal of Fungi. - 10 : 3 (2024), p.1-18. -
További szerzők:	Antal Károly Varga Kinga Gila Csaba Barnabás (1994-) (biotechnológus, biomérnök) Pócsi István (1961-) (vegyész)
Pályázati támogatás:	K 131767 Egyéb TKP2021-EGA-20 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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