Találati lista | Tudóstér

001-es BibID:	BIBFORM119680
035-os BibID:	(Scopus)85186557977
Első szerző:	Farkas Árpád
Cím:	Comparative study of the inhalation parameters of COPD patients through NEXThaler® and Ellipta® dry powder inhalers / Árpád Farkas, Alpár Horváth, Izolda Réti, Norbert Ilyés, Botond Havadtői, Tamás Kovács, Balázs Sánta, Gábor Tomisa, Péter Czaun, Gabriella Gálffy
Dátum:	2024
ISSN:	0954-6111
Megjegyzések:	The deposition of dry powder aerosol drugs depends on the inhalation parameters of the patients through the inhaler. These data are not directly measured in clinical practice. Their prediction based on the routinely measured spirometric data could help in choosing the appropriate device and optimizing the therapy. The aim of this study was to perform inhalation experiments to find correlations between inhalation parameters of COPD patients through two DPI devices and their native spirometric data, gender, age and disease severity. Another goal was to establish relationships between peak inspiratory flows through NEXThaler? and Ellipta? inhalers and their statistical determinants. Breathing parameters of 113 COPD patients were measured by normal spirometry and while inhaling through the two DPIs. Statistical analysis of the measured data was performed. The average values of peak inspiratory flow through the devices (PIFdev) were 68.4 L/min and 78.0 L/min for NEXThaler? and Ellipta?, respectively. PIFdev values were significantly higher for males than for females, but differences upon age, BMI and disease severity group were not significant. PIFdev values correlated best with their native spirometric counterparts (PIF) and linear relationships between them were revealed. Current results may be used in the future to predict the success of inhalation of COPD patients through DPI devices, which may help in the inhaler choice. By choosing the appropriate device-drug pair for each patient the lung dose can be increased and the efficiency of the therapy improved. Further results of the clinical study will be the subject of a next publication.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk COPD management Dry powder inhaler Patient and device specific inhalation parameters Peak inhalation flow
Megjelenés:	Respiratory Medicine. - 224 (2024), p. 1-8. -
További szerzők:	Horváth Alpár Réti Izolda Ilyés Norbert Havadtői Botond Kovács Tamás (1985-) (általános orvos) Sánta Balázs Tomisa Gábor Czaun Péter Gálffy Gabriella
Pályázati támogatás:	NKFIA 2021- 1.1.4-GYORSÍTÓSÁV-2022 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: