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001-es BibID:	BIBFORM120449
Első szerző:	Reda, Gebrehaweria Kidane (Phd hallgató)
Cím:	Expression of nutrient sensing genes mediate the effect of dietary unpredictability in Japanese quails / Reda Gebrehaweria K., Ndunguru Sawadi F., Csernus Brigitta, Szabó Csaba, Czeglédi Levente, Lendvai Ádám Z.
Dátum:	2024
Megjegyzések:	Dietary fluctuation is a common phenomenon in an organism's life and can compel them to change their mechanisms for growth, reproduction, immunity, and lifespan. These fluctuations hold evolutionary significance as they prompt diverse physiological and behavioural responses. Understanding animals' molecular mechanisms of adaptation to unpredictable changes in dietary availability is an essential question in animal research. Previous studies have proposed that one such signalling pathway, nutrient-sensing pathway, mediates systemic and cellular nutritional status hence regulates growth, reproduction and healthspan. Our previous study into varying degrees of dietary restriction in Japanese quails revealed significant changes in expression of nutrient sensing genes. To explore this further, we designed a study involved a combination of predictable feeding (control or 40% restricted feeding) and daily unpredictable feeding to Japanese quails, aimed to discern if unpredictable feed supply influence gene expression and fitness variables differently compared to control and consistently restricted birds. The research involved housing quails individually for 16 days and monitoring gene expression, body weight, egg laying, and egg morphology. Results revealed intriguing findings. Unpredictable feeding reduced body weight significantly in females but not in males, while a 40% dietary restriction lowered body weight in both sexes. However, only the 40% restriction notably affected egg laying and egg morphology. Gene expression analysis showed distinct patterns in nutrient-sensing genes. In the female groups, there was a notable reduction in the expression of insulin-like growth factor-1 and mechanistic target of rapamycin genes in both the unpredictable and restricted groups. Conversely, Forkhead box O1, Unc-51-like autophagy-activating kinases, autophagy genes (ATG9A and ATG5) and, unexpectedly, ribosomal protein S6 kinase 1 displayed an increasing trend in the constantly restricted and/or unpredictably fed groups. In males, all genes showed no significant variation although the trend mirrors what is observed in females. This study sheds light on how unpredictable dietary fluctuations impact gene expression and fitness traits. It also uncovers sex-specific variations in response to dietary changes.
ISBN:	978-615-6457-43-1
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok előadáskivonat könyvrészlet Gene expression Japanese quail nutrient sensing pathway unpredictable feeding
Megjelenés:	II. Magyar Agrártudományi Doktoranduszok Szimpóziuma / szerk. Hajdú Péter. - p. 27. -
További szerzők:	Ndunguru, Sawadi Fransisco (1980-) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Szabó Csaba (1968-) (agrármérnök) Czeglédi Levente (1977-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus)
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