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001-es BibID:	BIBFORM120622
035-os BibID:	(Scopus)85128187085 (WoS)000862476100016
Első szerző:	Mendogni, Paolo
Cím:	Surgical resection of Masaoka stage III thymic epithelial tumours with great vessels involvement : a retrospective multicentric analysis from the European Society of Thoracic Surgeons thymic database / Paolo Mendogni, Alper Toker, Bernhard Moser, Florentino Hernando Trancho, Clemens Aigner, Ivan Gomes Bravio, Nuria Maria Novoa, Laureano Molins, Lorena Costardi, Luca Voltolini, Nicoletta Pia Ardò, Bram Verdonck, Luca Ampollini, Charlambos Zisis, Vitaly Barmin, Attila Enyedi, Enrico Ruffini, Dirk Van Raemdonck, Pascal-Alexandre Thomas, Walter Weder, Gaetano Rocco, Alessandro Brunelli, Frank C. Detterbeck, Federico Venuta, Pierre-Emmanuel Falcoz, Davide Tosi, Gianluca Bonitta, Mario Nosotti, European Association of Thoracic Surgeons (ESTS) Thymic Working Group Participating Centers
Dátum:	2022
ISSN:	1010-7940
Megjegyzések:	OBJECTIVES: The aim of this study was to analyse the outcomes of an international cohort of patients affected by Masaoka stage III thymic epithelial tumours with vascular involvement and treated by surgery. METHODS: Study design was the observational multicentre retrospective cohort study. Data were extracted from the European Society of Thoracic Surgeons thymic database; additional variables were collected. Inclusion criteria were as follows: stage III (Masaoka-Koga) thymic epithelial tumours; surgery with radical intention; clinical or pathological great vessels involvement; and radiologically suspected or diagnosed intraoperatively. Outcome items were analysed. RESULTS: Sixty-five patients submitted to surgery from 2001 to 2017 fulfilled inclusion criteria. Thymoma and thymic carcinoma patients did not differ for demographics and clinical characteristics. The majority of great vessel treated were superior vena cava or innominate veins (72.3%). Eleven patients (16.9%) had postoperative cardiopulmonary complications; vascular stenosis was observed in 3 patients (4.6%). The multivariable Cox analysis for disease-free survival showed an increased hazard of recurrence for thymic carcinoma (hazard ratio = 3.59; 95% confidence interval: 1.66-7.78, P = 0.001). The 1-, 3-, 5-and 10-year overall survival rates were 0.86, 0.84, 0.81, and 0.53, respectively. There was no significant difference in overall survival according to resection status or between thymoma and thimic carcinoma. The univariable Cox regression model did not show an increased hazard of death for myasthenic patients considering all resection status and for patients who received neoadjuvant therapy. CONCLUSIONS: We observed that clinical outcomes of patients treated for stage III thymic epithelial tumours with vascular involvement are satisfactory suggesting to increase the confidence in dealing with these complex surgeries. Complete resection should be achieved, even though extensive vascular reconstructions are required.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Thymic tumours Thymoma Great vessels Thymectomy Recurrence Survival
Megjelenés:	European Journal Of Cardio-Thoracic Surgery. - 62 : 4 (2022), p. 1-11. -
További szerzők:	Toker, Alper Moser, Bernhard Trancho, Florentino Hernando Aigner, Clemens Bravio, Ivan Gomes Novoa, Nuria Maria Molins, Laureano Costardi, Lorena Voltolini, Luca Ardò, Nicoletta Pia Verdonck, Bram Ampollini, Luca Zisis, Charlambos Barmin, Vitaly Enyedi Attila (1975-) (sebész) Ruffini, Enrico Raemdonck, Dirk Van Thomas, Pascal Alexandre Weder, Walter Rocco, Gaetano Brunelli, Alessandro Detterbeck, Frank C. Venuta, Federico Falcoz, Pierre-Emmanuel Tosi, Davide Bonitta, Gianluca Nosotti, Mario Ozkan, Berker Cmenoglu, Berk Thanner, Jürgen Olivero, Carlos Fraile Alvarado, Rodriguez Boada, Marc Bongiolatti, Stefano Sollitto, Francesco Schil, Paul Van Bocchialini, Giovanni Brioude, Geoffrey European Association of Thoracic Surgeons (ESTS) Thymic Working Group Participating Centers
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