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001-es BibID:	BIBFORM121477
035-os BibID:	(Scopus)85124551136 (WoS)000752203700001
Első szerző:	Zhai, Ziyi
Cím:	Eugenol restrains abdominal aortic aneurysm progression with down-regulations on NF-?B and COX-2 / Ziyi Zhai, Xianjing Zhang, Yuchao Ding, Ziming Huang, Qian Li, Mingyue Zheng, Kenka Cho, Zhihui Dong, Weiguo Fu, Zaixing Chen, Baohong Jiang
Dátum:	2022
ISSN:	0951-418X
Megjegyzések:	Abdominal aortic aneurysm (AAA) is a lethal disease without available medicine for treatment. This study aimed to evaluate the efficiency of eugenol (4-allyl2-methoxyphenol) against AAA and the underlying mechanism. Eugenol is the major bioactive component of clove. A mouse AAA model was established through porcine pancreatic elastase (PPE) incubation peri-adventitially and 1% 3-aminopropanonitrile (BAPN) diet. Continuous AAA progression from day 0 to day 15 was observed after PPE plus BAPN treatment, according to the AAA diameter and histopathological evaluation. Accompanying with AAA progression, sustained increased expressions of CD68, COX-2 and NF-?B were observed through immunofluorescence assay. After elucidation the efficiency of eugenol against AAA progression by AAA diameter, hematoxylin?eosin staining and orcein staining, the down-regulations of eugenol on COX-2 and NF-?B were further detected by immunohistochemistry and western blot. Eugenol not only blocked AAA expansion and protected the integrity of aortic structure in a dose-dependent manner, but also held high oral bioavailability. Excellent efficiency, high oral bioavailability and down-regulation on COX-2/NF-?B endowed eugenol great potential for future AAA therapy
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk abdominal aortic aneurysm COX-2 eugenol NF-?B
Megjelenés:	Phytotherapy Research. - 36 : 2 (2022), p. 928-937. -
További szerzők:	Zhang, Xianjing Ding, Yuchao (1995-) (Ph.D. hallgató) Huang, Ziming Li, Qian Zheng, Mingyue Cho, Kenka Dong, Zhihui Fu, Weiguo Chen, Zaixing Jiang, Baohong
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