Összesen 1 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM122029
Első szerző:Lieber Attila
Cím:The role of immunotherapy in early stage and metastatic NSCLC / Attila Lieber, Attila Makai, Zsuzsanna Orosz, Tamás Kardos, Susil Joe Isaac, Ilona Tornyi, Nora Bittner
Dátum:2024
Megjegyzések:In the past decade we have seen new advances and by that remarkable progress in therapeutic possibilities of non-small cell lung cancer (NSCLC). Among cytostatic therapies with new approaches in molecularly targeted therapies, we see new development in a wide range of applications for immunotherapies. In this review we discuss the new potential modalities for the use of immune checkpoint inhibitors (ICIs) in frontline, including ? early stage (perioperative) and metastatic setting. The perioperative use of ICIs in both neoadjuvant and adjuvant setting may show benefit for patients. In early-stage NSCLC (from stage IIB and above) multimodal approach is recommended as gold standard for the treatment. After surgical resection platinum-based adjuvant chemotherapy was the standard of care for many years. Based on the benefit in disease free survival, the approval of adjuvant atezolizumab and adjuvant pembrolizumab were a significant breakthrough. In metastatic setting, the use of immune checkpoint inhibitor with chemotherapy, regardless of PD-L1 expression or ICI alone (PD-L1 expression equal or greater than 50%) improves overall survival and progression-free survival as well.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
NSCLC
PD-(L)1
ICI
perioperative
metastatic
Megjelenés:Pathology and Oncology Research. - "Accepted by Publisher" (2024). -
További szerzők:Makai Attila (1987-) (tüdőgyógyász szakorvos) Orosz Zsuzsanna (1974-) (Orvos) Kardos Tamás (1980-) (pulmonológus, klinikai onkológus) Susil, Joe Isaac Tornyi Ilona (1982-) (molekuláris biológus) Bittner Nóra (1963-) (orvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1