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001-es BibID:	BIBFORM122074
Első szerző:	Kovács Attila István (pszichiáter szakorvos)
Cím:	The potential use of dimethyltryptamine against ischemia-reperfusion injury of the brain / Attila Kovacs, Anna Mathe, Ede Frecska
Dátum:	2024
ISSN:	2639-3220
Megjegyzések:	Ischemia-reperfusion injury (IRI) is the outcome of two intertwined pathological processes resulting from the shortage of blood flow to tissues and the subsequent restoration of circulation to a previously ischemic area. IRI (sometimes just one side of the dyad) remains one of the most challenging problem in several branches of emergency medicine. Mitochondrial and endoplasmic reticulum dysfunction is a crucial pathological factor involved in the development of IRI. The sigma-1 receptor (Sig1-R) is an intracellular chaperone molecule located between the mitochondria and endoplasmic reticulum with an apparent physiological role to regulate signaling between these cell organelles and serves a safety mechanism against cellular stress. Therefore, amelioration of IRI is reasonable expected by the activation of the Sig1-R chaperone. Indeed, under cellular stress Sig1-R agonists improve mitochondrial respiration and optimize endoplasmic reticulum function by sustaining high-energy phosphate synthesis. The discovery that N,N-dimethyltryptamine (DMT) is an endogenous agonist of the Sig1-R may shed light on yet undiscovered physiological mechanisms and therapeutic potentials of this controversial hallucinogenic compound. In this article, the authors briefly overview the function of Sig1-R in cellular bioenergetics with a focus on the processes involved in IRI and summarize the results of their in vitro and in vivo DMT studies aiming at mitigating IRI. The authors conclude that the effect of DMT may involve a universal role in cellular protective mechanisms suggesting therapeutic potentials against different components and types of IRIs emerging in local and generalized brain ischemia after stroke or cardiac arrest.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk dimetiltriptamin hallucinogének szigma-1 receptor iszkémiás-reperfúziós károsodás stroke
Megjelenés:	Journal of Neuroscience and Neurological Disorders. - 8 : 1 (2024), p. 050-056. -
További szerzők:	Máthé Anna Beáta (1995-) (egészségpszichológus) Frecska Ede (1953-) (pszichiáter)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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