Találati lista | Tudóstér

001-es BibID:	BIBFORM122413
Első szerző:	Lendvai Ádám Zoltán (biológus)
Cím:	IGF-1 induces sex-specific oxidative damage and mortality in a songbird / Ádám Z. Lendvai, Zsófia Tóth, Katharina Mahr, Janka Pénzes, Sarah Vogel-Kindgen, Bruno A. Gander, Csongor I. Vágási
Dátum:	2024
ISSN:	0029-8549
Megjegyzések:	The insulin-like growth factor-1 (IGF-1) is a pleiotropic hormone that regulates essential life-history traits and is known for its major contribution to determining individual ageing processes. High levels of IGF-1 have been linked to increased mortality and are hypothesised to cause oxidative stress. This effect has been observed in laboratory animals, but whether it pertains to wild vertebrates has not been tested. This is surprising because studying the mechanisms that shape individual differences in lifespan is important to understanding mortality patterns in populations of free-living animals. We tested this hypothesis under semi-natural conditions by simulating elevated IGF-1 levels in captive bearded reedlings, a songbird species with an exceptionally fast pace of life. We subcutaneously injected slow-release biodegradable microspheres loaded with IGF-1 and achieved a sys-temic 3.7-fold increase of the hormone within the natural range for at least 24 h. Oxidative damage to lipids showed marked sexual differences: it significantly increased the day after the manipulation in treated males and returned to baseline levels four days post-treatment, while no treatment effect was apparent in females. Although there was no overall difference in survival between the treatment groups, high initial (pre-treatment) IGF-1 and low post-treatment plasma malondialdehyde levels were associated with enhanced survival prospects in males. These results suggest that males may be more susceptible to IGF-1-induced oxidative stress than females and quickly restoring oxidative balance may be related to fitness. IGF-1 levels evolve under opposing selection forces, and natural variation in this hormone's level may reflect the outcome of individual optimization.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény hazai lapban folyóiratcikk IGF-1 élethossz fiziológia madár
Megjelenés:	Oecologia. - "Accepted by Publisher" : - (2024), p. -. -
További szerzők:	Tóth Zsófia (1991-) (biológus) Mahr, Katharina Pénzes Janka Vogel-Kindgen, Sarah Gander, Bruno A. Vágási Csongor István
Pályázati támogatás:	K139021 OTKA EFOP-3.6.1-16-2016-00022 EFOP 2019-2.1.11-TÉT-2019-00043 Egyéb
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: