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001-es BibID:	BIBFORM122624
035-os BibID:	(Scopus)85193519552 (WoS)001266122300001
Első szerző:	Olsen, Thomas
Cím:	Dietary sulfur amino acid restriction in humans with overweight and obesity: Evidence of an altered plasma and urine sulfurome, and a novel metabolic signature that correlates with loss of fat mass and adipose tissue gene expressionn / Thomas Olsen, Kathrine J. Vinknes, Kristýna Barvíková, Emma Stolt, Sindre Lee-Ødegård, Hannibal Troensegaard, Hanna Johannessen, Amany Elshorbagy, Jitka Sokolová, Jakub Krijt, Michaela Kŕížková, Tamás Ditrói, Péter Nagy, Bente Øvrebø, Helga Refsum, Magne Thoresen, Kjetil Retterstøl , Viktor Kožich
Dátum:	2024
ISSN:	2213-2317
Megjegyzések:	Background: In animals, dietary sulfur amino acid restriction (SAAR) improves metabolic health, possibly mediated by altering sulfur amino acid metabolism and enhanced anti-obesogenic processes in adipose tissue. Aim: To assess the effects of SAAR over time on the plasma and urine SAA-related metabolites (sulfurome) in humans with overweight and obesity, and explore whether such changes were associated with body weight, body fat and adipose tissue gene expression. Methods: Fifty-nine subjects were randomly allocated to SAAR (-2 g SAA, n = 31) or a control diet (-5.6 g SAA, n = 28) consisting of plant-based whole-foods and supplemented with capsules to titrate contents of SAA. Sulfurome metabolites in plasma and urine at baseline, 4 and 8 weeks were measured using HPLC and LC-MS/MS. mRNA-sequencing of subcutaneous white adipose tissue (scWAT) was performed to assess changes in gene expression. Data were analyzed with mixed model regression. Principal component analyses (PCA) were performed on the sulfurome data to identify potential signatures characterizing the response to SAAR. Results: SAAR led to marked decrease of the main urinary excretion product sulfate (p < 0.001) and plasma and/ or 24-h urine concentrations of cystathionine, sulfite, thiosulfate, H2S, hypotaurine and taurine. PCA revealed a distinct metabolic signature related to decreased transsulfuration and H2S catabolism that predicted greater weight loss and android fat mass loss in SAAR vs. controls (all pinteraction < 0.05). This signature correlated positively with scWAT expression of genes in the tricarboxylic acid cycle, electron transport and 13-oxidation (FDR = 0.02). Conclusion: SAAR leads to distinct alterations of the plasma and urine sulfurome in humans, and predicted increased loss of weight and android fat mass, and adipose tissue lipolytic gene expression in scWAT. Our data suggest that SAA are linked to obesogenic processes and that SAAR may be useful for obesity and related disorders.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Adipose tissue Cysteine Gene expression Hydrogen sulfide Methionine Randomized controlled trial Sulfur amino acid restriction Transsulfuration
Megjelenés:	Redox Biology. - 73 (2024), p. 1-14. -
További szerzők:	Vinknes, Kathrine J. Barvíková, Kristýna Stolt, Emma Lee-Ødegård, Sindre Troensegaard, Hannibal Johannessen, Hanna Elshorbagy, Amany Sokolová, Jitka Krijt, Jakub Křížková, Michaela Ditrói Tamás (1989-) (vegyész) Nagy Péter (1976-) (vegyész) Øvrebø, Bente Refsum, Helga Thoresen, Magne Retterstøl, Kjetil Kožich, Viktor
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