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001-es BibID:	BIBFORM122639
035-os BibID:	(Scopus)85192746584 (WOS)001219973300001
Első szerző:	Vadadokhau, Uladzislau
Cím:	Examination of the Complex Molecular Landscape in Obesity and Type 2 Diabetes / Uladzislau Vadadokhau, Imre Varga, Miklós Káplár, Miklós Emri, Éva Csősz
Dátum:	2024
ISSN:	1661-6596 1422-0067
Megjegyzések:	The escalating prevalence of metabolic disorders, notably type 2 diabetes (T2D) and obesity, presents a critical global health challenge, necessitating deeper insights into their molecular underpinnings. Our study integrates proteomics and metabolomics analyses to delineate the complex molecular landscapes associated with T2D and obesity. Leveraging data from 130 subjects, including individuals with T2D and obesity as well as healthy controls, we elucidate distinct molecular signatures and identify novel biomarkers indicative of disease progression. Our comprehensive characterization of cardiometabolic proteins and serum metabolites unveils intricate networks of biomolecular interactions and highlights differential protein expression patterns between T2D and obesity cohorts. Pathway enrichment analyses reveal unique mechanisms underlying disease development and progression, while correlation analyses elucidate the interplay between proteomics, metabolomics, and clinical parameters. Furthermore, network analyses underscore the interconnectedness of cardiometabolic proteins and provide insights into their roles in disease pathogenesis. Our findings may help to refine diagnostic strategies and inform the development of personalized interventions, heralding a new era in precision medicine and healthcare innovation. Through the integration of multi-omics approaches and advanced analytics, our study offers a crucial framework for deciphering the intricate molecular underpinnings of metabolic disorders and paving the way for transformative therapeutic strategies. ? 2024 by the authors.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk data integration metabolomics obesity proteomics type 2 diabetes
Megjelenés:	International Journal Of Molecular Sciences. - 25 : 9 (2024), p. 1-13. -
További szerzők:	Varga Imre (1979-) (fizikus, informatikus) Káplár Miklós (1965-) (belgyógyász, diabetológus) Emri Miklós (1962-) (fizikus) Csősz Éva (1977-) (biokémikus, molekuláris biológus)
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