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001-es BibID:	BIBFORM122707
035-os BibID:	(Scopus)85197924008 (WoS)001258910400001
Első szerző:	Rostás Róbert (Orvos)
Cím:	Correlation of single-fiber electromyography studies and functional status in patients with amyotrophic lateral sclerosis / Róbert Rostás, István Fekete, László Horváth, Sándor Márton, Klára Fekete
Dátum:	2024
ISSN:	2391-5463 1911-2092
Megjegyzések:	Objective ? Our aim was to examine the significance of single-fiber electromyography (SFEMG) in patients diagnosed with amyotrophic lateral sclerosis (ALS) and determine the best correlating parameter with SFEMG parameters and clinical scales across different muscles including facial muscles. Methods ? SFEMG examinations were conducted on the extensor digitorum (ED), frontalis, and orbicularis oculi muscles. Mean jitter, percentage of increased jitter, fiber density (FD), and impulse blocking percentage were compared to reference values and functional scales. Results ? Significant differences (p < 0.001) were observed between the patients' SFEMG results and reference values in all muscles. Significant correlations were found between SFEMG parameters and clinical scales, particularly when considering both FD and jitter. A notable value of the ALS Functional Rating Scale Revised (ALSFRS-R) was detected in all muscles: 31 points in the ED muscle, 30 in the orbicularis oculi muscle, and 31 in the frontalis muscle. Below this ALSFRS-R threshold, the percentage of increased jitter was higher, while FD remained relatively low. Conclusion ? SFEMG examination emerges as a valuable tool for better understanding ALS and holds potential for assessing prognosis. Combined jitter and FD analysis showed the strongest correlation with clinical scales. In addition to the EDmuscle, the orbicularis oculimusclemay be important in the assessment.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk amyotrophic lateral sclerosis fiber density jitter orbicularis oculi muscle frontalis muscle
Megjelenés:	Open Medicine. - 19 : 1 (2024), p. 1-13. -
További szerzők:	Fekete István (1951-) (neurológus, pszichiáter) Horváth László (1973-) (gyógyszerész) Márton Sándor (1965-) (matematikus) Fekete Klára (1978-) (neurológus)
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