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001-es BibID:	BIBFORM122719
035-os BibID:	(Scopus)85194748692 (WOS)001235480200002
Első szerző:	Du, Wenjia
Cím:	Antidepressant-induced membrane trafficking regulates bloodbrain barrier permeability / Wenjia Du, Huanhuan Chen, Ilona Gróf, Lucien Lemaitre, Alexandra Bocsik, Adrian Perdyan, Jakub Mieczkowski, Mária A. Deli, Tibor Hortobágyi, Qi Wan, Oleg O. Glebov
Dátum:	2024
ISSN:	1359-4184
Megjegyzések:	As the most prescribed psychotropic drugs in current medical practice, antidepressant drugs (ADs) of the selective serotonin reuptake inhibitor (SSRI) class represent prime candidates for drug repurposing. The mechanisms underlying their mode of action, however, remain unclear. Here, we show that common SSRIs and selected representatives of other AD classes bidirectionally regulate fluid-phase uptake at therapeutic concentrations and below. We further characterize membrane trafficking induced by a canonical SSRI fluvoxamine to show that it involves enhancement of clathrin-mediated endocytosis, endosomal system, and exocytosis. RNA sequencing analysis showed few fluvoxamine-associated differences, consistent with the effect being independent of gene expression. Fluvoxamine-induced increase in membrane trafficking boosted transcytosis in cell-based blood-brain barrier models, while a single injection of fluvoxamine was sufficient to enable brain accumulation of a fluid-phase fluorescent tracer in vivo. These findings reveal modulation of membrane trafficking by ADs as a possible cellular mechanism of action and indicate their clinical repositioning potential for regulating drug delivery to the brain. ? The Author(s) 2024.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Molecular Psychiatry. - [Epub ahead of print] (2024). -
További szerzők:	Chen, Huanhuan Gróf Ilona Lemaitre, Lucien Bocsik Alexandra Perdyan, Adrian Mieczkowski, Jakub Deli Mária A. Hortobágyi Tibor (1965-) (patológus) Wan, Qi Glebov, Oleg O.
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