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001-es BibID:	BIBFORM122767
035-os BibID:	(WoS)001281644800048 (Scopus)85198844931
Első szerző:	Kusza Szilvia (agrármérnök)
Cím:	Insights into the genomic homogeneity of Moroccan indigenous sheep breeds though the lens of runs of homozygosity / Szilvia Kusza, Bouabid Badaoui, George Wanjala
Dátum:	2024
ISSN:	2045-2322
Megjegyzések:	Numerous studies have indicated that Morocco`s indigenous sheep breeds are genetically homogenous, posing a risk to their survival in the challenging harsh climate conditions where they predominantly inhabit. To understand the genetic behind genetic homogeneity through the lens of runs of homozygosity (ROH), we analyzed the whole genome sequences of fve indigenous sheep breeds (Beni Guil, Ouled Djellal, D`man, Sardi, Timahdite and Admixed).The results from principal component, admixture, Fst, and neighbour joining tree analyses consistently showed a homogenous genetic structure. This structure was characterized by an average length of 1.83 Mb for runs of homozygosity (ROH) segments, with a limited number of long ROH segments (24-48 Mb and> 48 Mb). The most common ROH segments were those ranging from 1-6 Mb. The most signifcant regions of homozygosity (ROH Islands) were mostly observed in two chromosomes, namely Chr1 and Chr5. Specifcally, ROH Islands were exclusively discovered in the Ouled Djellal breed on Chr1, whereas Chr5 exhibited ROH Islands in all breeds. The analysis of ROH Island and iHS technique was employed to detect signatures of selection on Chr1 and Chr5. The results indicate that Chr5 had a high level of homogeneity, with the same genes being discovered across all breeds. In contrast, Chr1 displays some genetic variances between breeds. Genes identifed on Chr5 included SLC39A1, IL23A, CAST, IL5, IL13, and IL4 which are responsible for immune response while genes identifed on Chr1 include SOD1, SLAMF9, RTP4, CLDN1, and PRKAA2. ROH segment profle and efective population sizes patterns suggests that the genetic uniformity of studied breeds is the outcome of events that transpired between 250 and 300 generations ago. This research not only contributes to the understanding of ROH distribution across breeds but helps design and implement native sheep breeding and conservation strategies in Morocco. Future research, incorporating a broader sample size and utilizing the pangenome for reference, is recommended to further elucidate these breeds` genomic landscapes and adaptive mechanisms.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Genomic homogeneity Indigenous sheep Morocco ROH
Megjelenés:	Scientific Reports. - 14 : 1 (2024), p. 1-11. -
További szerzők:	Badaoui, Bouabid (1979-) (animal genetics engineer) Wanjala, George (1984-) (Animal scientist)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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