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001-es BibID:	BIBFORM123168
Első szerző:	Ács-Szabó Lajos (biológus)
Cím:	Understanding the molecular mechanisms of human diseases: the benefits of fission yeasts / Lajos Acs-Szabó, Laszlo Attila Papp, Ida Miklós
Dátum:	2024
ISSN:	2311-2638
Megjegyzések:	The role of model organisms such as yeasts in life science research is crucial. Although the baker's yeast (Saccharomyces cerevisiae) is the most popular model among yeasts, the contribution of the ?ssion yeasts (Schizosaccharomyces) to life science is also indisputable. Since both types of yeasts share several thousands of common orthologous genes with humans, they provide a simple research platform to investigate many fundamental molecular mechanisms and functions, thereby contributing to the understanding of the background of human diseases. In this review, we would like to highlight the many advantages of ?ssion yeasts over budding yeasts. The usefulness of ?ssion yeasts in virus research is shown as an example, presenting the most important research results related to the Human Immunode?ciency Virus Type 1 (HIV-1) Vpr protein. Besides, the potential role of ?ssion yeasts in the study of prion biology is also discussed. Furthermore, we are keen to promote the uprising model yeast Schizosaccharomyces japonicus, which is a dimorphic species in the ?ssion yeast genus. We propose the hyphal growth of S. japonicus as an unusual opportunity as a model to study the invadopodia of human cancer cells since the two seemingly different cell types can be compared along fundamental features. Here we also collect the latest laboratory protocols and bioinformatics tools for the ?ssion yeasts to highlight the many possibilities available to the research community. In addition, we present several limiting factors that everyone should be aware of when working with yeast models.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk fission yeast budding yeast human disease fungal hyphae tumor invadopodia molecular tools
Megjelenés:	Microbial Cell. - 11 : 1 (2024), p. 288-311. -
További szerzők:	Papp László Attila (1986-) (genetikus) Miklós Ida (1962-) (biológus)
Pályázati támogatás:	TKP2021-EGA-18 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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