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001-es BibID:	BIBFORM123331
035-os BibID:	(scopus)85202639288
Első szerző:	Csikos Csaba (orvos)
Cím:	Predicting Complete Cytoreduction with Preoperative [18F]FDG PET/CT in Patients with Ovarian Cancer : a Systematic Review and Meta-Analysis / Csikos Csaba, Czina Péter, Molnár Szabolcs, Kovács Anna, Garai Ildikó, Krasznai Zoárd
Dátum:	2024
ISSN:	2075-4418
Megjegyzések:	The cornerstone of ovarian cancer treatment is complete surgical cytoreduction. The gold-standard option in the absence of extra-abdominal metastases and intra-abdominal inoperable circumstances is primary cytoreductive surgery (CRS). However, achieving complete cytoreduction is challenging, and only possible in a selected patient population. Preoperative imaging modalities such as [18F]FDG PET/CT could be useful in patient selection for cytoreductive surgery. In our sys- tematic review and meta-analysis, we aimed to evaluate the role of preoperative [18F]FDG PET/CT in predicting complete cytoreduction in primary and secondary debulking surgeries. Publications were pooled from two databases (PubMed, Mendeley) with predefined keywords "(ovarian cancer) AND (FDG OR PET) AND (cytoreductive surgery)". The quality of the included studies was assessed with the Prediction model Risk Of Bias Assessment Tool (PROBAST). During statistical analysis, MetaDiSc 1.4 software and the DerSimonian?Laird method (random effects models) were used. Primary and secondary cytoreductive surgeries were evaluated. Pooled sensitivities, specificities, positive predictive values (PPVs), and negative predictive values (NPVs) were calculated and statistically ana- lyzed. Results were presented in forest plot diagrams and summary receiver operating characteristic (SROC) curves. Overall, eight publications were included in our meta-analysis. Four publications presented results of primary, three presented results of secondary cytoreductions, and two presented data related to both primary and secondary surgery. Pooled sensitivities, specificities, and positive and negative predictive values were the following: in the case of primary surgeries: 0.65 (95% CI 0.60?0.71), 0.73 (95% CI 0.66?0.80), 0.82 (95% CI 0.77?0.87), 0.52 (95% CI 0.46?0.59); and in the case of secondary surgeries: 0.91 (95% CI 0.84?0.95), 0.48 (95% CI 0.30?0.67), 0.88 (95% CI 0.81?0.93), 0.56 (95% CI 0.35?0.75), respectively. The PPVs of [18F]FDG PET/CT proved to be higher in cases of secondary debulking surgeries; therefore, it can be a valuable predictor of complete successful secondary cytoreduction.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk ovarian cancer cytoreductive surgery preoperative [18F]FDG PET/CT complete debulking prediction
Megjelenés:	Diagnostics. - 14 : 16 (2024), p. 1-14.-
További szerzők:	Czina Péter Molnár Szabolcs (1987-) (szülész-nőgyógyász szakorvos) Kovács Anna Rebeka (1993-) (általános orvos) Garai Ildikó (1966-) (radiológus) Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász)
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