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001-es BibID:	BIBFORM123542
035-os BibID:	(scopus)85202750993
Első szerző:	Al Ashkar, Habib
Cím:	Association of CETP Gene Polymorphisms and Haplotypes with Acute Heart Rate Response to Exercise / Al Ashkar Habib, Kovács Nóra, Veres-Balajti Ilona, Ádány Róza, Pikó Péter
Dátum:	2024
ISSN:	1661-6596 1422-0067
Megjegyzések:	Polymorphisms in the cholesteryl ester transfer protein (CETP) gene are known to be strongly associated with increased cardiovascular risk, primarily through their effects on the lipid profile and consequently on atherosclerotic risk. The acute heart rate response (AHRR) to physical activity is closely related to individual cardiovascular health. This study aimed to investigate the effect of CETP gene polymorphisms on AHRR. Our analysis examines the association of five sin- gle nucleotide polymorphisms (SNPs; rs1532624, rs5882, rs708272, rs7499892, and rs9989419) and their haplotypes (H) in the CETP gene with AHRR in 607 people from the Hungarian population. Individual AHRR in the present study was assessed using the YMCA 3-min step test and was esti- mated as the difference between resting and post-exercise heart rate, i.e., delta heart rate (?HR). To exclude the direct confounding effect of the CETP gene on the lipid profile, adjustments for TG and HDL-C levels, next to conventional risk factors, were applied in the statistical analyses. Among the examined five SNPs, two showed a significant association with lower ?HR (rs1532624?Cdominant: B = ?8.41, p < 0.001; rs708272?Gdominant: B = ?8.33, p < 0.001) and reduced the risk of adverse AHRR (rs1532624?Cdominant: OR = 0.44, p = 0.004; rs708272?Gdominant: OR = 0.43, p = 0.003). Among the ten haplotypes, two showed significant association with lower ?HR (H3?CAGCA: B = ?6.81, p = 0.003; H9?CGGCG: B = ?14.64, p = 0.015) and lower risk of adverse AHRR (H3?CAGCA: OR = 0.58, p = 0.040; H9?CGGCG: OR = 0.05, p = 0.009) compared to the reference haplotype (H1?AGACG). Our study is the first to report a significant association between CETP gene poly- morphisms and AHRR. It also confirms that the association of the CETP gene with cardiovascular risk is mediated by changes in heart rate in response to physical activity, in addition to its effect on lipid profile.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk cardiovascular risk haplotype acute heart rate response cholesteryl ester transfer protein genomics
Megjelenés:	International Journal Of Molecular Sciences. - 25 : 16 (2024), p. 1-10.-
További szerzők:	Kovács Nóra (1989-) (népegészségügyi szakember) Veres-Balajti Ilona (1965-) (gyógytornász, egészségfejlesztő) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Pikó Péter (1987-) (biológus)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP TK2016-78 MTA Hungarian Research Network-HUN-REN (TKCS-2021/32) Egyéb National Research, Development, and Innovation Fund of Hungary K_20 programme Egyéb National Laboratory for Health Security Hungary (RRF-2.3.1-21-2022-00006) Egyéb ÚNKP-23-5-DE-494 Egyéb Janos Bolyai Research Scholarship (BO/00513/23/5) MTA
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