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001-es BibID:	BIBFORM124097
Első szerző:	Sipos Dávid
Cím:	Complex Diagnostic Challenges in Glioblastoma : The Role of 18F-FDOPA PET Imaging / Sipos David, Debreczeni-Máté Zsanett, Ritter Zsombor, Freihat Omar, Simon Mihály, Kovács Árpád
Dátum:	2024
ISSN:	1424-8247
Megjegyzések:	Abstract: Glioblastoma multiforme (GBM) remains one of the most aggressive and lethal forms of brain cancer, characterized by rapid proliferation and diffuse infiltration into the surrounding brain tissues. Despite advancements in therapeutic approaches, the prognosis for GBM patients is poor, with median survival times rarely exceeding 15 months post-diagnosis. An accurate diagnosis, treatment planning, and monitoring are crucial for improving patient outcomes. Core imaging modalities such as Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are indispensable in the initial diagnosis and ongoing management of GBM. Histopathology remains the gold standard for definitive diagnoses, guiding treatment by providing molecular and genetic insights into the tumor. Advanced imaging modalities, particularly positron emission tomography (PET), play a pivotal role in the management of GBM. Among these, 3,4-dihydroxy-6-[18F]-fluoro-L-phenylalanine ( 18F-FDOPA) PET has emerged as a powerful tool due to its superior specificity and sensitivity in detecting GBM and monitoring treatment responses. This introduction provides a comprehensive overview of the multifaceted role of 18F-FDOPA PET in GBM, covering its diagnostic accuracy, potential as a biomarker, integration into clinical workflows, impact on patient outcomes, technological and methodological advancements, comparative effectiveness with other PET tracers, and its costeffectiveness in clinical practice. Through these perspectives, we aim to underscore the significant contributions of 18F-FDOPA PET to the evolving landscape of GBM management and its potential to enhance both clinical and economic outcomes for patients afflicted with this formidable disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk glioblastoma diagnostic imaging MRI PET 18F-FDOPA
Megjelenés:	Pharmaceuticals. - 17 : 9 (2024), p. 1-16.-
További szerzők:	Debreczeni-Máté Zsanett Ritter Zsombor Freihat, Omar Simon Mihály (1981-) (Fizikus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus)
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