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001-es BibID:	BIBFORM124634
035-os BibID:	(WoS)001328801300044 (Scopus)85205527528
Első szerző:	Gaál Zsuzsanna (csecsemő-és gyermekgyógyász központi gyakornok)
Cím:	Implication of microRNAs as messengers of exercise adaptation in junior female triathlonists / Zsuzsanna Gaál, János Fodor, Tamás Oláh, Ivett Gabriella Szabó, Ildikó Balatoni, László Csernoch
Dátum:	2024
ISSN:	2045-2322
Megjegyzések:	While expression profile of muscle-specific miRNAs following endurance training is well-characterized, information about exercise-induced changes of metabolism-regulating miRNAs is limited, especially in female and junior athletes. Major aim of this study was to examine a set of miRNAs related to mitochondrial function and metabolism in highly professional junior female athletes. The Hungarian National Junior Triathlon Team (n?=?4), completed standardized running and cycling sessions. Expression levels of miR-133a, miR-210, miR-494 and miR-127-3p were determined by RT-qPCR in whole blood and serum samples, withdrawn directly before, and after the exercise, and 24 and 48 h later. The expression of miR-494, miR-127-3p and miR-210 showed strong correlation with each other. In serum, nearly significant increment of miR-127-3p levels was detected, that may be a novel biomarker of exercise adaptation. Its expression was significantly higher than that of miR-210. In whole blood, significantly higher miR-210 than miR-494 and miR-127-3p levels were observed. MiRNA expression profile of the youngest athlete was markedly different compared to others. Our results suggest that miRNAs related to mitochondrial function and metabolism are involved in exercise adaptation. The present study may facilitate further research with larger potential participant pools, contributing to improved prevention and treatment of chronic diseases of civilization.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Epigenetics miRNAs Physiology
Megjelenés:	Scientific Reports. - 14 : 1 (2024), p. 22858. -
További szerzők:	Fodor János (1973-) (élettanász, biotechnológus) Oláh Tamás (1983-) (élettanász) Szabó Ivett Gabriella (1995-) (biotechnológus, biológus) Balatoni Ildikó (1970-) (orvos) Csernoch László (1961-) (élettanász)
Pályázati támogatás:	K 137600 OTKA TKP2021-EGA-18 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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