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001-es BibID:	BIBFORM124648
Első szerző:	Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:	Bones or Stones : how Can We Apply Geophysical Techniques in Bone Research? / Zoltán Szekanecz, Anikó Besnyi, Péter Kónya, Judit Füri, Edit Király, Éva Bertalan, György Falus, Beatrix Udvardi, Viktória Kovács-Kis, László Andrássy, Gyula Maros, Tamás Fancsik, Zsófia Pethő, Izabella Gomez, Ágnes Horváth, Katalin Gulyás, Balázs Juhász, Katalin Hodosi, Zsuzsanna Sándor, Harjit P. Bhattoa, István J. Kovács
Dátum:	2024
ISSN:	1661-6596 1422-0067
Megjegyzések:	Some studies have used physical techniques for the assessment of bone structure and composition. However, very few studies applied multiple techniques, such as those described below, at the same time. The aim of our study was to determine the chemical and mineralogical/organic composition of bovine tibial bone samples using geophysical/geochemical reference techniques. X-ray diffraction (XRD), thermogravimetry (TG), Fourier-transform infrared spectrometry with at tenuated total reflectance accessory (FTIR-ATR), inductively coupled mass spectrometry (ICP-MS) and inductively coupled optical emission spectrometry (ICP-OES) were applied to measure the organic and inorganic composition of 14 bovine bone samples. In addition, peripheral quantitative CT (QCT) was used to assess BMD in these bones. We were able to define the total composition of the studied bone samples. ICP-OES and ICP-MS techniques were used to determine the major and trace element composition. The X-ray analysis could detect inorganic crystalline compounds of bones, such as bioapatite, and its degree of ordering, indicating whether the bones belong to a younger or older individual. The total volatile content of the samples was calculated using TG and resulted in about 35 weight% (wt%). This, together with the 65 wt% total resulting from the chemical analysis (i.e., inorganic components), yielded a total approaching 100 wt%. As a large portion of the volatile content (H2O, CO2 , etc.) was liberated from the organic components and, subordinately, from bioap atite, it could be concluded that the volatile-to-solid ratio of the examined bone samples was ~35:65. The FTIR-ATR analysis revealed that the organic portion consists of collagens containing amide groups, as their typical bands (OH, CH, CO, NC) were clearly identified in the infrared spectra. Numerous parameters of bone composition correlated with BMD as determined by QCT. In conclu sion, we performed a complex evaluation of bovine bones to test multiple geophysical/geochemical techniques in bone research in association with QCT bone densitometry. From a medical point of view, the composition of the studied bones could be reliably examined by these methods.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk bone X-ray diffraction thermogravimetry Fourier-transform infrared spectrometry with attenuated total reflectance accessory inductively coupled mass spectrometry inductively coupled optical emission spectrometry
Megjelenés:	International Journal Of Molecular Sciences. - 25 : 19 (2024), p. 1-16. -
További szerzők:	Besnyi Anikó Kónya Péter Füri Judit Király Edit Bertalan Éva Falus György (Budapest) Udvardi Beatrix (Budapest) Kovács-Kiss Viktória Andrássy László Maros Gyula Fancsik Tamás Pethő Zsófia (1981-) (reumatológus, immunológus) Gomez Izabella (1981-) (orvos) Horváth Ágnes (1985-) (reumatológus) Gulyás Katalin (reumatológus) Juhász Balázs (1973-) (orvos, onkológus) Hódosi Katalin Jakabné Sándor Zsuzsanna Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Kovács István János
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