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001-es BibID:	BIBFORM124993
035-os BibID:	(Scopus)85200812472 (WOS)001294526600001
Első szerző:	Balta, Cornel
Cím:	Chrysin-loaded calixarene-cyclodextrin ternary drug delivery system inhibits TGF-β and galectin-1 mediated pathways in diabetic liver fibrosis / Cornel Balta, Hildegard Herman, Alina Ciceu, Caterina Claudia Lepre, Bianca Mladin, Marcel Rosu, Daniela Oatis, Marina Russo, Victor Eduard Peteu, Mihaela Gherghiceanu, Ferenc Fenyvesi, Coralia Cotoraci, Maria Consiglia Trotta, Michele D`Amico, Anca Hermenean
Dátum:	2024
ISSN:	0006-2952
Megjegyzések:	This study investigated the efficacy of a new chrysin-loaded calixarene-cyclodextrin ternary drug delivery system (DDS) in reversing liver fibrosis in a mouse model of chronic diabetes. The system was designed to enhance the solubility and bioavailability of chrysin (CHR) and calixarene 0118 (OTX008). Adult male CD1 mice received streptozotocin (STZ) injections to induce diabetes. After 20 weeks, they underwent intraperitoneal treatments twice weekly for a two-week period. Histological analyses revealed that long-term hyperglycaemia increased liver fibrosis and altered hepatic ultrastructure, characterized by lipid accumulation, hepatic stellate cell activation, and collagen deposition. The treatment with the chrysin-loaded DDS restored liver structure closely to normal levels, as opposed to the minimal impact observed with sulfobutylated ?-cyclodextrin (SBECD) alone. The treatment significantly decreased serum activities of alanine /aspartate transaminases and reduced the gene expression of collagen type I (Col-I). It also modulated the transforming growth factor beta 1 (TGF-?1)/Smad signalling pathway, inhibiting the activation and proliferation of hepatic stellate cells. The treatment led to a downregulation of the TGF-?1 gene and its receptors TGF?R1 and TGF?R2, together with a decrease in Smad 2 and 3 mRNA levels. Conversely, Smad 7 mRNA expression was increased by the DDS. Furthermore, it downregulated galectin-1 (Gal-1) gene and protein levels, which correlated with fibrotic markers. In conclusion, the chrysin-loaded calixarene-cyclodextrin ternary DDS presents a promising therapeutic approach for diabetic liver fibrosis, effectively targeting fibrotic pathways and restoring hepatic function and structure. ? 2024
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Calixarene Chronic diabetes Chrysin Cyclodextrin Drug delivery system Liver fibrosis
Megjelenés:	Biochemical Pharmacology. - 229 (2024), p. 116474, p. 1-10. -
További szerzők:	Herman, Hildegard Ciceu, Alina Lepre, Caterina Claudia Mladin, Bianca Rosu, Marcel Oatis, Daniela Russo, Marina Peteu, Victor Eduard Gherghiceanu, Mihaela Fenyvesi Ferenc (1977-) (gyógyszerész, gyógyszertechnológus) Cotoraci, Coralia Trotta, Maria Consiglia D'Amico, Michele Hermenean, Anca
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