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001-es BibID:	BIBFORM125549
035-os BibID:	(Scopus)85198565447 (WOS)001280021700001
Első szerző:	Tóth Szilárd
Cím:	Synthesis and Systematic Investigation of Lepidiline A and Its Gold(I), Silver(I), and Copper(I) Complexes Using In Vitro Cancer Models and Multipotent Stem Cells / Tóth, Szilárd; Szlávik, Márton F.; Mandel, Réka; Fekecs, Fanni; Tusnády, Gábor; Vajda, Flóra; Varga, Nóra; Apáti, Ágota; Bényei, Attila; Paczal, Attila; Kotschy, András; Szakács, Gergely
Dátum:	2024
ISSN:	2470-1343
Megjegyzések:	The imidazole alkaloid lepidiline A from the root of Lepidium meyenii has a moderate to low in vitro anticancer effect. Our aim was to extend cytotoxicity investigations against a panel of cancer cells, including multidrug-resistant cancer cells, and multipotent stem cells. Lepidiline A is a N-heterocyclic carbene precursor, therefore a suitable ligand source for metal complexes. Thus, we synthesized lepidiline A and its copper(I), gold(I), and silver(I) complexes and tested them against ovarian, gastrointestinal, breast, and uterine cancer cells and bone marrow-derived and adipose-derived mesenchymal stem cells. Lepidiline A and its copper complex demonstrated moderate cytotoxicity, while silver and gold complexes exhibited significantly enhanced and consistent cytotoxicity against both cancer and stem cell lines. ABCB1 in the multidrug-resistant uterine sarcoma line conferred significant resistance against lepidiline A and the copper-lepidiline A complex, but not against the silver and gold complexes. Our results indicate that only the copper complex induced a significant and universal increase in the production of reactive oxygen species within cells. In summary, binding of metal ions to lepidiline A results in enhanced cytotoxicity with the nature of the metal ion playing a critical role in determining its properties. ? 2024 The Authors. Published by American Chemical Society
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	ACS Omega. - 9 : 29 (2024), p. 32226-32234. -
További szerzők:	Szlávik Márton F. Mandel Réka Fekecs Fanni Tusnády Gábor (1941-) (matematikus) Vajda Flóra Vanda Varga Nóra Apáti Ágota Bényei Attila (1962-) (vegyész) Paczal Attila Kotschy András Szakács Gergely
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