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001-es BibID:	BIBFORM125568
Első szerző:	Baranyi József (biomatematikus)
Cím:	Modelling the temporal trajectories of human milk components / Baranyi, József; Pacza, Tünde; Martins, Mayara L.; Thakkar, Sagar K.; Samuel, Tinu M.
Dátum:	2024
ISSN:	1471-2393
Megjegyzések:	BackgroundThis paper demonstrates how available data can be explored and utilized to conclude generic patterns in the temporal changes in Human Milk (HM) composition.MethodsThe temporal trajectories of selected human milk components (HMC-s) were described, in the first four months postpartum, by a primary model consisting of two phases: a short linear phase in the colostrum, triggered by the parturition; and a longer second phase, where the concentration of the component converges to a steady state. The model was fitted to data available in a recently published database of temporal HMC trajectories both at the levels of individual molecules (such as specific fatty acid, oligosaccharide, and mineral molecules) and molecule-groups (such as total protein, total fat).ResultsThe properties of the trajectories suggest that experimental designs should follow non-equidistant sampling times, with increasingly longer time intervals after the first week postpartum. A selected parameter, the final station-ary level, of the primary model was then studied as a function of geographical location (secondary modelling).ConclusionsWe found that the total variation of the concentration of specific HMC-s is dominantly due to the inher-ent biological differences between individual mothers and to less extent to the geographical location.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Food composition Human Milk Predictive modelling Saturation model Longitudinal data Error estimation
Megjelenés:	BMC Pregnancy and Childbirth. - 24 : 1 (2024), p. 1-13. -
További szerzők:	Pacza Tünde (1967-) (alkalmazott matematikus, informatikus) Martins, Mayara Lopes (1993-) Thakkar, Sagar K. Samuel, Tinu M.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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