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001-es BibID:	BIBFORM125754
035-os BibID:	(WoS)001358965800003 (Scopus)85209823280
Első szerző:	To Quoc, Thinh (gyógyszerész)
Cím:	The Role of Amphiphilic Compounds in Nasal Nanoparticles / Thinh To Quoc, Krisztina Bíró, Ágota Pető, Dóra Kósa, Ádám Haimhofer, István Lekli, Ádám Pallér, István Bak, Alexandra Gyöngyösi, Pálma Fehér, Ildikó Bácskay, Zoltán Ujhelyi
Dátum:	2024
ISSN:	1530-9932
Megjegyzések:	Nasal medications hold signifcant importance and are widely utilized due to their numerous advantageous properties, ofering a compelling route for both local and systemic therapeutic efects. Nowadays, the development of nasal particles under 1 micrometer is in the focus of much scientifc research. In our experiments, the use of innovative nanotechnology to increase the efectiveness of the active substance was of paramount importance. Our aim was to create solid nanoparticles that enable targeted and efective delivery of the active ingredient into the body. The innovation of this experimental series lies not only in highlighting the importance of amphiphilic compounds in enhancing penetration, but also in the fact that while most nasally administered formulations are in liquid form, our formulation is solid. Liquid formulations frequently sufer from the disadvantage of possible leakage during administration, which can reduce the bioavailability of the active ingredient. In our experiments we created novel drug delivery systems of fnely divided powders, which, thanks to the penetration enhancers, can be successfully administered. These enhancers facilitate the swift disintegration and penetration of the particles through the membrane. This represents a new direction in nasal drug delivery methods. The results of our trials are promising in the development of innovative pharmaceutical products and outline the role of amphiphilic compounds in more efcient utilization and targeted application of active substances. According to our results it can be concluded that this innovative approach not only addresses the common issues associated with liquid nasal formulations but also paves the way for more stable and efective delivery methods. The use of fnely divided powders for nasal delivery, enabled by penetration enhancers, represents a major breakthrough in the feld, providing a dependable alternative to conventional liquid formulations and ensuring improved therapeutic results.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk nanoformulations nasal drug delivery systems RPMI cells spray drying
Megjelenés:	AAPS PharmSciTech. - 25 : 8 (2024), p. 1-14. -
További szerzők:	Bíró Krisztina Pető Ágota (1994-) (gyógyszerész) Kósa Dóra (1994-) (gyógyszerész) Haimhoffer Ádám (1994-) (gyógyszerész) Lekli István (1981-) (gyógyszerész) Pallér Ádám Bak István (1975-) (vegyész, analitikus, farmakológus) Gyöngyösi Alexandra (1990-) (táplálkozástudományi szakember) Fehér Pálma (1976-) (gyógyszerész) Bácskay Ildikó (1969-) (gyógyszerész, gyógyszertechnológus) Ujhelyi Zoltán (1984-) (gyógyszerész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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