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001-es BibID:	BIBFORM125855
Első szerző:	Nagy Attila Csaba (megelőző orvostan és népegészségtan szakorvos, epidemiológus)
Cím:	Protective Influence of SGLT-2 Inhibitors Against Heart Failure in Type 2 Diabetes Mellitus Through Longitudinal Clinical Database Analysis / Attila Csaba Nagy, Ágnes Tóth, Natália Bak, Battamir Ulambayar, Amr Sayed Ghanem, Ferenc Sztanek
Dátum:	2024
ISSN:	2077-0383
Megjegyzések:	Background: Sodium?glucose co-transporter 2 (SGLT-2) inhibitors, initially designed for type 2 diabetes, promote glucose excretion and lower blood glucose. Newer analogs like empagliflozin and dapagliflozin improve cardiovascular outcomes through mechanisms other than glycemic control, including blood pressure reduction and anti-inflammatory effects. Given the high cardiovascular risk present in diabetes, our study aims to emphasize the cardioprotective benefits of SGLT-2 inhibitors as a preventive therapy for heart failure (HF) in high-risk T2DM patients. Methods: Using data from 2542 patients identified by the ICD-10 E11 code from 2016 to 2020, this longitudinal study excluded those with E10 codes or those undergoing insulin treatment to focus on non-insulin-dependent T2DM. a multiple logistic regression model assessed HF incidence while adjusting for demographics and HbA1c. Results: SGLT-2 inhibitor use significantly lowered the odds of heart failure events (OR = 0.55, 95% CI: 0.31?0.99, p = 0.046), with a significant difference by gender (OR = 0.45, 95% CI: 0.28?0.71, p = 0.001) and eGFR (OR = 0.98, 95% CI: 0.97?0.99, p = 0.004). Conclusions: The real-world data highlight SGLT-2 inhibitors as promising for HF prevention and broader cardiometabolic health in T2DM, with potential value in managing complex comorbid profiles.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk diabetes mellitus cardiovascular disease heart failure SGLT-2 inhibitors clinical laboratory tests
Megjelenés:	Journal of Clinical Medicine. - 13 : 23 (2024), p. 1-11. -
További szerzők:	Tóth Ágnes Bak Natália Ulambayar, Battamir (1986-) (orvos) Ghanem, Amr Sayed (1991-) (orvos, fogorvos) Sztanek Ferenc (1982-) (orvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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