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001-es BibID:	BIBFORM125942
035-os BibID:	(Scopus)85210516828 (WoS)001365219400001
Első szerző:	Faltinek, Lukáš
Cím:	Bispecific Thio-Linked Disaccharides as Inhibitors of Pseudomonas Aeruginosa Lectins LecA (PA-IL) and LecB (PAIIL) : dual-Targeting Strategy / Lukáš Faltinek, Filip Melicher, Viktor Kelemen, Erika Mező, Anikó Borbás, Michaela Wimmerová
Dátum:	2024
ISSN:	0947-6539 1521-3765
Megjegyzések:	Pseudomonas aeruginosa is a prevalent opportunistic human pathogen, particularly associated with cystic fibrosis. Among its virulence factors are the LecA and LecB lectins. Both lectins play an important role in the adhesion to the host cells and display cytotoxic activity. In this study, we successfully synthesized hardly hydrolysable carbohydrate ligands targeting these pathogenic lectins, including two bispecific glycans. The interactions between LecA/LecB lectins and synthetic glycans were evaluated using hemagglutination (yeast agglutination) inhibition assays, comparing their efficacy with corresponding monosaccharides. Additionally, the binding affinities of bispecific glycans were assessed using isothermal titration calorimetry (ITC). Structural insight into the lectin-ligand interaction was obtained by determining the crystal structures of LecA/ LecB lectins in complex with one of the bispecific ligands using X ray crystallography. This comprehensive investigation into the inhibitory potential of synthetic glycosides against P. aeruginosa lectins sheds light on their potential application in antimicrobial therapy.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk lectin Pseudomonas aeruginosa 1-thiofucose 1-thiogalactose bispecific lectin ligand
Megjelenés:	Chemistry-A European Journal. - 30 (2024), p. 1-10. -
További szerzők:	Melicher, Filip Kelemen Viktor (1992-) (gyógyszerész) Mező Erika (1986-) (vegyész) Borbás Anikó (1965-) (vegyész) Wimmerová, Michaela
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