Találati lista | Tudóstér

001-es BibID:	BIBFORM126140
Első szerző:	Hernyák Marcell
Cím:	Kallistatin as a Potential Marker of Therapeutic Response During Alpha-Lipoic Acid Treatment in Diabetic Patients with Sensorimotor Polyneuropathy / Hernyák Marcell, Tóth László Imre, Csiha Sára, Molnár Ágnes, Lőrincz Hajnalka, Paragh György, Harangi Mariann, Sztanek Ferenc
Dátum:	2024
ISSN:	1661-6596 1422-0067
Megjegyzések:	Diabetic sensorimotor neuropathy (DSPN) is strongly associated with the extent of cellular oxidative stress and endothelial dysfunction in type 2 diabetes (T2DM). Alpha-lipoic acid (ALA) attenuates the progression of DSPN through its antioxidant and vasculoprotective effects. Kallistatin has antioxidant and anti-inflammatory properties. We aimed to evaluate changes in kallistatin levels and markers of endothelial dysfunction in patients with T2DM and DSPN following six months of treatment with 600 mg/day of ALA. A total of 54 patients with T2DM and DSPN and 24 control patients with T2DM but without neuropathy participated in this study. The serum concentrations of kallistatin, ICAM-1, VCAM-1, oxLDL, VEGF, ADMA, and TNF-alpha were measured by an ELISA. Peripheral sensory neuropathy was assessed with neuropathy symptom questionnaires and determination of the current perception threshold. After ALA treatment, the level of kallistatin significantly decreased, as well as the levels of TNF-alpha and ADMA. Changes in kallistatin levels were positively correlated with changes in oxLDL. The improvement in DSPN symptoms following ALA treatment showed a positive correlation with changes in kallistatin, VEGF, oxLDL, and ADMA levels. Based on our results, kallistatin could represent a potential new biomarker for assessing therapeutic response during ALA treatment in patients with DSPN.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk alpha-lipoic acid diabetic sensorimotor neuropathy endothelial dysfunction kallistatin type 2 diabetes oxidative stress
Megjelenés:	International Journal Of Molecular Sciences. - 25 : 24 (2024), p. 1-14. -
További szerzők:	Tóth László (1997-) (orvos) Csiha Sára (1985-) (Biológus) Molnár Ágnes (1972-) (gyógytornász) Lőrincz Hajnalka (1986-) (biológus) Paragh György (1953-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Sztanek Ferenc (1982-) (orvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: