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001-es BibID:	BIBFORM126270
035-os BibID:	(scopus)85190160325 (wos)001201473600001
Első szerző:	Dekeyser, Cathérine
Cím:	Routine CSF parameters as predictors of disease course in multiple sclerosis : an MSBase cohort study / Dekeyser C., Hautekeete M., Cambron M., Van Pesch V., Patti F., Kuhle J., Khoury S., Lechner Scott J., Gerlach O., Lugaresi A., Maimone D., Surcinelli A., Grammond P., Kalincik T., Habek M., Willekens B., Macdonell R., Lalive P., Csepany T., Butzkueven H., Boz C., Tomassini V., Foschi M., Sánchez-Menoyo J. L., Altintas A., Mrabet S., Iuliano G., Sa M. J., Alroughani R., Karabudak R., Aguera-Morales E., Gray O., de Gans K., van der Walt A., McCombe P. A., Deri N., Garber J., Al-Asmi A., Skibina O., Duquette P., Cartechini E., Spitaleri D., Gouider R., Soysal A., Van Hijfte L., Slee M., Amato M. P., Buzzard K., Laureys G.
Dátum:	2024
ISSN:	0022-3050 1468-330X
Megjegyzések:	Background: It remains unclear whether routine cerebrospinal fluid (CSF) parameters can serve as predictors of multiple sclerosis (MS) disease course. Methods: This large-scale cohort study included persons with MS with CSF data documented in the MSBase registry. CSF parameters to predict time to reach confirmed Expanded Disability Status Scale (EDSS) scores 4, 6 and 7 and annualised relapse rate in the first 2 years after diagnosis (ARR2) were assessed using (cox) regression analysis. Results: In total, 11 245 participants were included of which 93.7% (n=10 533) were persons with relapsing-remitting MS (RRMS). In RRMS, the presence of CSF oligoclonal bands (OCBs) was associated with shorter time to disability milestones EDSS 4 (adjusted HR=1.272 (95% CI, 1.089 to 1.485), p=0.002), EDSS 6 (HR=1.314 (95% CI, 1.062 to 1.626), p=0.012) and EDSS 7 (HR=1.686 (95% CI, 1.111 to 2.558), p=0.014). On the other hand, the presence of CSF pleocytosis (?5 cells/?L) increased time to moderate disability (EDSS 4) in RRMS (HR=0.774 (95% CI, 0.632 to 0.948), p=0.013). None of the CSF variables were associated with time to disability milestones in persons with primary progressive MS (PPMS). The presence of CSF pleocytosis increased ARR2 in RRMS (adjusted R2=0.036, p=0.015). Conclusions: In RRMS, the presence of CSF OCBs predicts shorter time to disability milestones, whereas CSF pleocytosis could be protective. This could however not be found in PPMS. CSF pleocytosis is associated with short-term inflammatory disease activity in RRMS. CSF analysis provides prognostic information which could aid in clinical and therapeutic decision-making.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk CLINICAL NEUROLOGY CSF MULTIPLE SCLEROSIS NEUROIMMUNOLOGY
Megjelenés:	Journal of Neurology, Neurosurgery, and Psychiatry . - 95 : 11 (2024), p. 1021-1031. -
További szerzők:	Hautekeete, Matthias Cambron, Melissa Pesch, Vincent van Patti, Francesco Kuhle, Jens Khoury, Samia J. Lechner Scott, Jeanette Gerlach, Oliver Lugaresi, Alessandra Maimone, Davide Surcinelli, Andrea Grammond, Pierre Kalincik, Tomas Habek, Mario Willekens, Barbara Macdonell, Richard Lalive, Patrice H. Csépány Tünde (1956-) (neurológus, pszichiáter) Butzkueven, Helmut Boz, Cavit Tomassini, Valentina Foschi, Matteo Sanchez-Menoyo, Jose Altintas, Ayse Mrabet, Saloua Iuliano, Gerardo Sá, Maria José Alroughani, Raed Karabudak, Rana Aguera-Morales, Eduardo Gray, Orla de Gans, Koen Walt, Anneke van der McCombe, Pamela Deri, Norma Garber, Justin Al-Asmi, Abdullah Skibina, Olga Duquette, Pierre Cartechini, Elisabetta Spitaleri, Daniele Gouider, Riadh Soysal, Aysun Van Hijfte, Liesbeth Slee, Mark Amato, Maria Pia Buzzard, Katherine Laureys, Guy
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