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001-es BibID:	BIBFORM126273
035-os BibID:	(scopus)85210113292
Első szerző:	Siriratnam, Pakeeran
Cím:	Prevalence of Progression Independent of Relapse Activity and Relapse-Associated Worsening in Patients With AQP4-IgG-Positive NMOSD / Siriratnam P., Huda S, Van Der Walt A., Sanfilippo P. G., Sharmin S., Foong Y. C., Yeh W. Z., Zhu C., Khoury S. J., Csepany T., Willekens B., Etemadifar M., Ozakbas S., Nytrova P., Altintas A., Al-Asmi A., Ramo-Tello C. M., Laureys G., Patti F., Horakova D., Foschi M., Boz C., Mccombe P. A., Turkoglu R., Lechner-Scott J., Roos I., Kalincik T., Jokubaitis V. G., Butzkueven H., Monif M., MSBase
Dátum:	2024
ISSN:	0028-3878 1526-632X
Megjegyzések:	Objectives In aquaporin-4 antibody?positive neuromyelitis optica spectrum disorder (AQP4-IgG NMOSD), disability accrual is mostly attributed to relapses. This study aimed to assess the prevalence of progression independent of relapse activity (PIRA) and relapse-associated worsening (RAW) in AQP4-IgG NMOSD. Methods This was a retrospective cohort study of patients with AQP4-IgG NMOSD enrolled in the MSBase international data registry. Patients required a minimum of 3 recorded Expanded Disability Status Scale (EDSS) scores: baseline, event, and a 6-month confirmation score. Presence and absence of relapses between the baseline and event EDSS scores determined RAW and PIRA, respectively. Descriptive statistics were used to present the results. Results A total of 181 patients followed for a median of 4.5 years (Q1 1.7, Q3 7.8) were included. Most patients were female (88.4%), and the median age at disease onset was 38.1 years. Overall, 4 patients (2.2%) developed 5 incidences of PIRA and 13 patients developed RAW (7.2%). Discussion This multicenter study highlights that PIRA is very rare in AQP4-IgG NMOSD. Limitations of this study include the sole focus of overall EDSS to measure disability, lack of requirement for a second EDSS score to confirm baseline EDSS, and the absence of magnetic resonance imaging information for all patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk NMOSD PIRA RAW
Megjelenés:	Neurology. - 103 : 12 (2024), p. 1-8. -
További szerzők:	Huda, Saif Walt, Anneke van der Sanfilippo, Paul Sharmin, Sifat Foong, Yi Chao Yeh, Wei Zhen Zhu, Chao Khoury, Samia J. Csépány Tünde (1956-) (neurológus, pszichiáter) Willekens, Barbara Etemadifar, Masoud Ozakbas, Serkan Nytrova, Petra Altintas, Ayse Al-Asmi, Abdullah Ramo-Tello, Cristina Laureys, Guy Patti, Francesco Horakova, Dana Foschi, Matteo Boz, Cavit McCombe, Pamela Turkoglu, Recai Lechner-Scott, Jeannette Roos, Izanne Kalincik, Tomas Jokubaitis, Vilija Butzkueven, Helmut Monif, Mastura MSBase Study Group
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