Találati lista | Tudóstér

001-es BibID:	bibEBI00019290
Első szerző:	Panyi György (biofizikus)
Cím:	Cross talk between activation and slow inactivation gates of Shaker potassium channels / Panyi G., Deutsch C.
Dátum:	2006
Megjegyzések:	This study addresses the energetic coupling between the activation and slow inactivation gates of Shaker potassium channels. To track the status of the activation gate in inactivated channels that are nonconducting, we used two functional assays: the accessibility of a cysteine residue engineered into the protein lining the pore cavity (V474C) and the liberation by depolarization of a Cs(+) ion trapped behind the closed activation gate. We determined that the rate of activation gate movement depends on the state of the inactivation gate. A closed inactivation gate favors faster opening and slower closing of the activation gate. We also show that hyperpolarization closes the activation gate long before a channel recovers from inactivation. Because activation and slow inactivation are ubiquitous gating processes in potassium channels, the cross talk between them is likely to be a fundamental factor in controlling ion flux across membranes.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	The Journal of General Physiology. - 128 : 5 (2006), p. 547-559. -
További szerzők:	Deutsch, Carol
Internet cím:	elektronikus változat
Borító:
Saját polcon: