Találati lista | Tudóstér

001-es BibID:	BIBFORM003513
Első szerző:	Lőcsey Lajos (belgyógyász, nephrológus)
Cím:	Relationship between serum paraoxonase activity and adipokines levels in renal transplanted patients / Lajos Lőcsey, Ildikó Seres, Ferenc Sztanek, László Szabó, László Asztalos, György Paragh
Dátum:	2008
Megjegyzések:	Introduction: Increased oxidative stress and inflammation are associated with atherosclerotic coronary disease in renal transplanted patients. HDL-associated paraoxonase (PON1) prevents LDL-C from oxidation providing protection against atherosclerotic and coronary artery disease. Previous studies shown that serum leptin, adiponectin concentrations are elevated in patients with chronic kidney disease. AIM: our aim to investigate the connection between serum paraoxonase activity, renal function, adiponectin and leptin levels in renal transplanted patients. Methods: 79 transplanted patients (38 males, 41 females, age: 49,01 +-14.00 ys) were included int he study. We examined in fasting serum creatinine, cystatin C, homocysteine, CRP, glucose and lipids. PON1 activity was determined spectrophotometrically. Serum adiponectin and leptin levels were measured by ELISA method. Results: Our patients had hypercholesterolaemia, high LDL and ApoB levels and paralel with improved renal function decreased cystatin C and homocysteine levels (p<0.001). We devided our pts into two groups according to BMI. In obes pts (BMI>30 kgm2, n=14) was significantly higher LDL (p<0.05) and leptin concentrations (58.06 vs.15.16 ng/ml, p<0.01) than in malnourished pts (n=9). We not found significant difference between serum adiponectin levels (15,12 vs. 17.34 ug/ml) and PON 1 activity (91.45 vs. 101.20 U/l) in obese and malnourished renal transplanted pts. Between serum leptin concentration and PON1 activity was not significant negative correlation. After transplantation was significant negativ correlation between serum PON 1 activity and improved renal function (p<0.01). Conclusions: In dyslipidaemic, obes transplanted pts have high LDL, leptin concentrations, and paraoxonase activity not significant correlation between leptin, adiponectin and CRP levels. With improved renal function significant increased PON1 activity.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok előadáskivonat
Megjelenés:	XXII. International Congress of the Transplantation Society 10-14 August 2008, Sydney, Australia. - p. 5.
További szerzők:	Seres Ildikó (1954-) (biokémikus) Sztanek Ferenc (1982-) (orvos) Szabó László (1975-) (sebész) Asztalos László (1951-) (sebész) Paragh György (1953-) (belgyógyász)
Internet cím:	elektronikus változat
Borító:
Saját polcon: