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001-es BibID:	BIBFORM003894
Első szerző:	Antal András
Cím:	Abdominal surgery performed under general anesthesia increases somatostatin-like immunoreactivity in human serum / Andras Antal, Jozsef Nemeth, Janos Szolcsanyi, Gabor Pozsgai
Dátum:	2008
Megjegyzések:	It has been established in animals that somatostatin (SST) is released from pain-activated sensory nerve endings and exerts systemic antinociceptive and anti-inflammatory actions. The aim of this study was to investigate the changes of SST-like immunoreactivity (SST-LI) in human serum before, immediately after and 2 h after surgical operations. Methods: 25 patients were enrolled in the study. Laparoscopic cholecystectomy, abdominal wall hernia or inguinal hernia operations were performed under combined anesthesia. A 5-ml blood sample was drawn from each patient, the blood was centrifuged and the serum frozen. SSTLI was determined from the defrosted samples by radioimmunoassay. Results: Abdominal surgical operations induced a significant increase of SST-LI in the serum. 2 h later it was restored in the cases of laparoscopic interventions but still remained elevated after hernia surgeries. Conclusions: In this human study we showed for the first time that surgical interventions elevate the endogenous SST-LI in human serum. It is assumed that the released SST is derived from theactivated sensory nerves. Since antinociceptive and anti-inflammatory effects of neural SST have already been established in laboratory animals, we presume that this endogenous protective mechanism also operates in humans.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Somatostatin-like immunoreactivity Abdominal surgery Radioimmunoassay Sensory nerves
Megjelenés:	Neuroimmunomodulation. - 15 : 3 (2008), p. 153-156. -
További szerzők:	Németh József (1954-) (vegyész, analitikus) Szolcsányi János (Pécs) Pozsgai Gábor
Internet cím:	elektronikus változat DOI
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