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001-es BibID:BIBFORM004670
Első szerző:Péter Mózes (orvos, neuroradiológus) ifj.
Cím:Blockage of human T lymphocyte Kv1.3 channels by Pi1, a novel class of scorpion toxin / Peter, M., Jr., Hajdu, P., Varga, Z., Damjanovich, S., Possani, L. D., Panyi, G., Gaspar, R.
Dátum:2000
Megjegyzések:Using the patch-clamp technique we determined that Pandinus imperator toxin Pi1, a recently described peptide toxin having four disulfide bridges instead of the usual three in scorpion toxins, blocked Kv1.3 channels of human T lymphocytes from the extracellular side with a 1:1 stoichiometry. Kv1.3 block was instantaneous and removable with toxin-free extracellular solution. The toxin did not influence activation or inactivation of the channels. We found that Pi1 blocked Kv1.3 with less affinity (K(d) = 11.4 nM) than the structurally related three disulfide bridge containing toxins Pi2 (50 pM) and Pi3 (0.5 nM). The fourth disulfide bridge in Pi1 had no influence on the channel binding ability of the toxin; the less effective block was due to differences in amino acid side chain properties at positions 11 and 35.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Amino Acid Sequence
Amino Acids
Animal
chemistry
Disulfides
drug effects
Human
Hungary
Kinetics
Lymphocytes
metabolism
Molecular Sequence Data
Patch-Clamp Techniques
pharmacology
Potassium
Potassium Channels
Protein Binding
Scorpion Venoms
Scorpions
Sequence Homology,Amino Acid
Support,Non-U.S.Gov't
T-Lymphocytes
Time Factors
Toxins
Megjelenés:Biochemical and Biophysical Research Communications. - 278 : 1 (2000), p. 34-37. -
További szerzők:Hajdu Péter (1975-) (biofizikus) Varga Zoltán (1969-) (biofizikus, szakfordító) Damjanovich Sándor (1936-2017) (biofizikus) Possani, Lourival Domingos Panyi György (1966-) (biofizikus) Gáspár Rezső (1944-) (biofizikus)
Internet cím:elektronikus változat
DOI
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