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001-es BibID:	BIBFORM004882
Első szerző:	Panyi György (biofizikus)
Cím:	Biophysical and pharmacological aspects of K+ channels in T lymphocytes / Panyi, G.
Dátum:	2005
ISSN:	0175-7571
Megjegyzések:	Voltage-gated Kv1.3 and Ca2+-activated IKCa1 K+ channels play a pivotal role in antigen-dependent activation and proliferation of lymphocytes.These channels primarily determine the membrane potential of T cells, and thus regulate the magnitude of the Ca2+ signal required for efficient gene transcription and subsequent proliferation. Although these facts are generally well described and acknowledged, some recent discoveries have motivated research in this field, which is reviewed herein along with the basic biophysical characterization of Kv1.3 and IKCa1. The discovery of T cell subset-specific expression of Kv1.3 points towards the potential therapeutic use of high affinity and high specificity Kv1.3 inhibitors as specific immunosuppressors in the management of autoimmune diseases, such as Multiple Sclerosis. In meeting the demands for an ideal immunosuppressor, several laboratories have discovered potent natural Kv1.3- specific inhibitors and engineered peptides which have a better pharmacological profile based on the biophysical characterization of the interaction surface between the channel pore and the toxins. In contrast to the generally accepted permissive role of Kv1.3 during lymphocyte activation, the discovery of the localization of Kv1.3 in the immunological synapse might open new opportunities in the regulation of T cell activation by this channel species.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Amino Acid Sequence Animals Antigens Antigens,CD3 Autoimmune Diseases Biophysics biosynthesis Calcium Cell Proliferation Cells chemistry cytology Electrophysiology Fluorescence Resonance Energy Transfer Humans Hungary immunology Immunosuppressive Agents Lymphocyte Activation Lymphocytes metabolism methods Models,Biological Molecular Sequence Data Multiple Sclerosis Peptides pharmacology Potassium Protein Structure,Tertiary Research Sequence Homology,Amino Acid Support Synapses T-Lymphocytes therapeutic use Time Factors Toxins article Research Support
Megjelenés:	European Biophysics Journal. - 34 : 6 (2005), p. 515-529. -
Internet cím:	elektronikus változat
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