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001-es BibID:	BIBFORM006009
Első szerző:	Szegedi Gyula (belgyógyász, immunológus)
Cím:	Antigen density on the surface of mononuclear cells in SLE / Szegedi, G., Surányi, P., Damjanovich, S.
Dátum:	1987
Megjegyzések:	Searching for the cause of the known immunological abnormalities in systemic lupus erythematosus (SLE), the density of cell surface antigens was measured after immunofluorescent staining in a cell sorter. The densities of CD3, CD4, CD5, CD8 and sIgM lymphocyte antigens were the same on patients' lymphocytes as on lymphocytes from healthy subjects. The intensity of HLA-DR immunofluorescence was found to be decreased on patients' monocytes, while the expression of HLA-DR on lymphocytes of patients with SLE hardly differed from that in healthy subjects. Pretreatment of normal mononuclear cells with patients' sera free from immune complexes decreased the binding of anti-HLA-DR antibody to normal monocytes, but it hardly caused alteration on lymphocytes. After culturing, the expression of HLA-DR antigen on patients' monocytes became the same as on normal cells. A causal role of anti-HLA-DR autoantibodies is suggested and discussed.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban analysis Antigens,Differentiation Antigens,Surface Autoantibodies Flow Cytometry Fluorescent Antibody Technique HLA Antigens Human Hungary Immunoglobulins,Surface immunology Leukocytes,Mononuclear Lupus Erythematosus,Systemic Lymphocytes Monocytes
Megjelenés:	Immunology Letters. - 15 : 3 (1987), p. 243-247. -
További szerzők:	Surányi Péter Damjanovich Sándor (1936-2017) (biofizikus)
Internet cím:	elektronikus változat DOI
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