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001-es BibID:	BIBFORM006064
035-os BibID:	WOS:A1996UY72200007
Első szerző:	Bacsó Zsolt (biofizikus)
Cím:	Changes in membrane potential of target cells promotes cytotoxic activity of effector T lymphocytes / Zsolt Bacsó, János Matkó, János Szöllősi, Rezső Gáspár, Sándor Damjanovich
Dátum:	1996
Megjegyzések:	The effector function of CD8+ lymphocytes depends on recognition by the TcR-CD3 complex of an oligopeptide presented by an MHC class I molecule on target cells. Recently it has been shown that MHC class I molecules change their conformation upon depolarization of human B lymphoblastoid JY cells. We studied here the effects of changes in membrane potential of target cells on the function of cytotoxic T lymphocytes (CTL). Selective alterations of plasma membrane potential of JY target cells were achieved by treatments with specific ionophore molecules as well as with Na(+)-K(+)-ATPase inhibitor, while the cytotoxic lymphocytes were not influenced. The plasma membrane was depolarized by gramicidin D and ouabain, while hyperpolarization was induced by valinomycin treatment. Alterations of the resting membrane potential of target cells in both direction resulted in an enhanced cytotoxic activity. The observed changes in cytolytic activities of cytotoxic T effectors may have a more general biological significance, namely apoptotic cells become depolarized after a given time, moreover neoplastic and virus infected cells also frequently show decreased membrane potential. A more efficient recognition of these cells by CTL is supposed to enhance the efficiency of their elimination, as well.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Cytotoxicity,Immunologic Human Hungary immunology Lymphocytes Membrane Potentials Support,Non-U.S.Gov't T-Lymphocytes T-Lymphocytes,Cytotoxic Tumor Cells,Cultured Valinomycin egyetemen (Magyarországon) készült közlemény
Megjelenés:	Immunology Letters. - 51 : 3 (1996), p. 175-180. -
További szerzők:	Matkó János (1952-) (biológus) Szöllősi János (1953-) (biofizikus) Gáspár Rezső (1944-) (biofizikus) Damjanovich Sándor (1936-2017) (biofizikus)
Internet cím:	elektronikus változat DOI
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