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001-es BibID:BIBFORM006415
Első szerző:Kósa Karolina (népegészségügyi szakember)
Cím:TPA induces transglutaminase C and inhibits cell growth in the colon carcinoma cell line SW620 / Kosa, K., Rosenberg, M. I., Chiantore, M. V., De Luca, L. M.
Dátum:1997
ISSN:0006-291X (Print)
Megjegyzések:In contrast to most other systems, TPA induced TGc activity and protein in SW620 human colon carcinoma cells. This induction was accompanied by cell growth inhibition and increased apoptosis. The general protein kinase-C inhibitor GF-109203X blocked the induction of TGc by TPA, whereas the specific inhibitor of the PKC alpha isoform, the indocarbazole Go6976, reduced it by 40%. These PKC inhibitors had similar inhibitory effects on TPA increased apoptosis and inhibition of cell growth, suggesting that the observed actions of TPA are mediated by PKC, and a close connection between TGc activity, increased apoptosis and cell growth inhibition. We conclude that TPA may offer new approaches in the management of colon cancer cell growth.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Apoptosis/drug effects
Cell Division/ drug effects
Colonic Neoplasms/ drug therapy/ enzymology/pathology
Dose-Response Relationship, Drug
Enzyme Activation/drug effects
Enzyme Induction/drug effects
Humans
Protein Kinase C/metabolism
Tetradecanoylphorbol Acetate/administration & dosage/ pharmacology
Thymidine/metabolism
Transglutaminases/ biosynthesis
Tumor Cells, Cultured
Megjelenés:Biochemical and Biophysical Research Communications. - 232 : 3 (1997), p. 737-741. -
További szerzők:Rosenberg, M. I. Chiantore, M. V. De Luca, Luigi M.
Internet cím:elektronikus változat
elektronikus változat
DOI
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