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001-es BibID:	BIBFORM007064
Első szerző:	Halloran, Margaret M.
Cím:	The role of an epithelial neutrophil-activating peptide-78-like protein in rat adjuvant-induced arthritis / Margaret M. Halloran, James M. Woods, Robert M. Strieter, Zoltan Szekanecz, Michael V. Volin, Shigeru Hosaka, G. Kenneth Haines III, Steven L. Kunkel, Marie D. Burdick, Alfred Walz, Alisa E. Koch
Dátum:	1999
ISSN:	0022-1767 (Print)
Megjegyzések:	The chemokine, epithelial neutrophil-activating peptide-78 (ENA-78), is a potent neutrophil chemotaxin whose expression is increased in inflamed synovial tissue and fluid in human rheumatoid arthritis compared with osteoarthritis. Since ENA-78 has been implicated in the pathogenesis of RA, we examined the expression of an ENA-78-like protein during the development of rat adjuvant-induced arthritis (AIA). Using an ELISA assay, we found increased levels of antigenic ENA-78-like protein in the sera of AIA animals compared with control normal animals by day 7 postadjuvant injection. ENA-78-like protein levels continued to increase as AIA developed. ENA-78-like protein levels in joint homogenates were increased in AIA animals later in the development of the disease, by day 18 during maximal arthritis, compared with control animals. Expression of ENA-78-like protein in both the AIA serum and joint correlated with the progression of inflammation of the joints. Anti-human ENA-78 administered before disease onset modified the severity of AIA, while administration of anti-ENA-78 after clinical onset of AIA did not modify the disease. These data support a role for an ENA-78-like protein as an important chemokine in the progression and maintenance of AIA.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Animals Arthritis, Experimental Cell Movement Chemokine CXCL5 Chemokines, CXC Epithelial Cells Female Immune Sera Injections, Intraperitoneal Interleukin-8 derivatives Neutrophil Activation Neutrophils Peritoneum Rats Rats, Inbred Lew Synovial Fluid Tarsus, Animal Time Factors
Megjelenés:	The Journal of Immunology 162 : 12 (1999), p. 7492-7500. -
További szerzők:	Woods, James M. Strieter, Robert M. Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Volin, Michael V. Hosaka, Shigeru Haines, Kenneth G. III. Kunkel, Steven L. Burdick, Marie D. Walz, Alfred Koch, Alisa E.
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