Találati lista | Tudóstér

001-es BibID:	BIBFORM007105
Első szerző:	Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:	Differential expression of the urokinase receptor (CD87) in arthritic and normal synovial tissues / Szekanecz, Z., Haines, G. K., Koch, A. E.
Dátum:	1997
ISSN:	0021-9746 (Print)
Megjegyzések:	To determine whether the urokinase plasminogen activator receptor (u-PAR; CD87) exhibits a possible pathogenic role in rheumatoid and osteoarthritis. METHODS: A semiquantitative, indirect immunoperoxidase histochemical analysis was performed on frozen synovial tissue sections. The recently characterised monoclonal antibody 10G7 recognising transfectants bearing u-PAR was used. Synovial tissue was obtained from 10 patients with rheumatoid arthritis, 10 patients with osteoarthritis, and four normal subjects. RESULTS: u-PAR was expressed on 70-90% of synovial tissue lining cells and subsynovial, interstitial macrophages from the arthritis patients, but only on a few myeloid cells from the normal subjects. It was also present on more endothelial cells from the rheumatoid and osteoarthritis patients, than from normal synovial tissue. CONCLUSIONS: Plasminogen activators are important in joint destruction underlying arthritis. The up-regulated expression of u-PAR in diseased versus normal synovial tissue suggests a role for this antigen in the inflammatory and angiogenic mechanisms underlying rheumatoid and osteoarthritis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Arthritis, Rheumatoid Humans Immunohistochemistry Macrophages Osteoarthritis Receptors, Cell Surface Receptors, Urokinase Plasminogen Activator Synovial Membrane
Megjelenés:	Journal of Clinical Pathology. - 50 : 4 (1997), p. 314-319. -
További szerzők:	Haines, G. Kenneth Koch, Alisa E.
Internet cím:	elektronikus változat
Borító:
Saját polcon: