Találati lista | Tudóstér

001-es BibID:	BIBFORM007107
Első szerző:	Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:	Temporal expression of inflammatory cytokines and chemokines in rat adjuvant-induced arthritis / Szekanecz, Z., Halloran, M. M., Volin, M. V., Woods, J. M., Strieter, R. M., Kenneth Haines, G. 3rd, Kunkel, S. L., Burdick, M. D., Koch, A. E.
Dátum:	2000
ISSN:	0004-3591 (Print)
Megjegyzések:	To examine cytokine and chemokine production during the evolution of rat adjuvant-induced arthritis (AIA), a model of rheumatoid arthritis. METHODS: Clinical and laboratory assessment of the course of AIA was performed over a 47-day period. Levels of the cytokines tumor necrosis factor a (TNFalpha), interleukin-1beta (IL-1beta), and IL-6, as well as levels of the chemokines macrophage inflammatory protein 1alpha (MIP-1alpha) and JE, the murine homolog of monocyte chemoattractant protein 1, were determined by enzyme-linked immunosorbent assay in the sera and joints of AIA and control rats. Synovia from AIA rats were (immuno)histochemically analyzed. Results of cytokine and chemokine measurements were correlated with clinical and laboratory markers of inflammation and histology. RESULTS: Early (before day 14 post adjuvant injection) and later phases of AIA could be distinguished. Cytokine and chemokine production was increased in AIA versus control rats. The production of TNFalpha, IL-1beta, MIP-1alpha, and, as determined earlier, epithelial neutrophil-activating peptide 78-like protein was abundant prior to and during the course of AIA, while that of IL-6 and JE was elevated in the late phase of AIA. Cytokine and chemokine levels were correlated with the clinical symptoms of arthritis and blood neutrophil counts. Joint levels of IL-1beta showed correlation with synovial lining proliferation and neutrophil ingress into AIA synovium. CONCLUSION: Cytokines and chemokines are involved in the clinical, laboratory, and histologic changes underlying AIA. The production of these mediators may be temporally and spatially regulated. These findings may be important for the optimal timing of cytokine and chemokine targeting.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Animals Arthritis, Experimental Chemokines Cytokines Enzyme-Linked Immunosorbent Assay Female Inflammation Mediators Joints Kinetics Rats Rats, Inbred Lew Reference Values Synovitis Time Factors
Megjelenés:	Arthritis and Rheumatism. - 43 : 6 (2000), p. 1266-1277. -
További szerzők:	Halloran, Margaret M. Volin, Michael V. Woods, James M. Strieter, Robert M. Haines, Kenneth G. III. Kunkel, Steven L. Burdick, Marie D. Koch, Alisa E.
Internet cím:	elektronikus változat elektronikus változat Szerző által megadott URL DOI
Borító:
Saját polcon: