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001-es BibID:BIBFORM007128
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Intercellular adhesion molecule-1 (ICAM-1) expression and soluble ICAM-1 (sICAM-1) production by cytokine-activated human aortic endothelial cells : a possible role for ICAM-1 and sICAM-1 in atherosclerotic aortic aneurysms / Szekanecz, Z., Shah, M. R., Pearce, W. H., Koch, A. E.
Dátum:1994
ISSN:0009-9104 (Print)
Megjegyzések:The interactions of inflammatory cells, cytokines, and cell adhesion molecules (CAM) may be important in the pathogenesis of vascular diseases such as abdominal aortic aneurysms (AAA), in which inflammation plays a role. The aim of this study was to investigate the pathogenic role of ICAM-1, a molecule involved in leucocyte-endothelial interactions, in vascular inflammation. ELISA of human explant culture supernatants revealed a four-fold increase in sICAM-1 production by AAA (n = 9) versus normal (n = 8) aortic explants. Human aortic endothelial cell (hAEC) culture was used for further studies as an in vitro model for aortic inflammatory conditions. Tumour necrosis factor-alpha (TNF-alpha) or IL-1 beta treatment of hAEC resulted in an up to 1.8-fold significant increase in sICAM-1 production compared with resting cells. In addition, the expression of ICAM-1 on cytokine-stimulated versus resting hAEC was measured by radioimmunoassay. TNF-alpha significantly induced ICAM-1 expression on these cells. These results suggest that different forms of ICAM-1, present on or released by the activated aortic endothelium, may be involved in leucocyte adhesion to and migration into the vessel wall.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Aorta, Abdominal
Aortic Aneurysm, Abdominal
Arteriosclerosis
Cells, Cultured
Culture Media, Conditioned
Cytokines
Endothelium, Vascular
Enzyme-Linked Immunosorbent Assay
HLA-DR Antigens
Humans
Intercellular Adhesion Molecule-1
Radioimmunoassay
Megjelenés:Clinical and Experimental Immunology. - 98 : 2 (1994), p. 337-343. -
További szerzők:Shah, M. R. Pearce, W. H. Koch, Alisa E.
Internet cím:elektronikus változat
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