Összesen 1 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM010351
035-os BibID:(WOS)000266994100004 (scopus)65649131520
Első szerző:Goda Katalin (biofizikus)
Cím:Multidrug resistance through the spectacle of P-glycoprotein / Katalin Goda, Zsolt Bacsó, Gábor Szabó
Dátum:2009
ISSN:1568-0096 (Print)
Megjegyzések:P-glycoprotein (Pgp), coded for by the mdr1 gene, is one of the ABC transporters held responsible for the phenomenon of multidrug resistance (mdr), which is reflected by a rapidly escalating failure of chemotherapy with different classes of cytotoxic agents: anthracyclins, vinca alkaloids, taxanes, epipodophylotoxins. Although overcoming resistance conveyed by Pgp alone may not be sufficient for reaching effective treatment, the abundance of observations available for this paradigmatic multidrug transporter at both in vitro and in vivo setting is a tempting ground for an updated assessment of the main currents of mdr research. In this review we attempt to help keep track of the features of Pgp-mediated drug transport that serve as the major starting points for ongoing efforts of mdr reversal. We will analyze the slowly narrowing gaps that prevail between our ever increasing understanding at the protein, cell and organism level, focusing on the molecular interactions involving Pgp.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Algorithms
Alkaloids
Amino Acids
analysis
anthracycline
Antibodies
antineoplastic activity
Antineoplastic Agents
Apoptosis
Ascites
beta cyclodextrin derivative
beta methylcyclodextrin
binding affinity
binding site
Biological Transport
Biophysics
blood
Brain
cancer chemotherapy
cancer resistance
Capillaries
Caveolae
Cell Membrane
Cells
ceramide
chemistry
Cho Cells
Cholesterol
Cloning,Molecular
colchicine
concentration response
cyclodextrin derivative
cyclosporin A
Daunorubicin
Dexamethasone
Dna
doxorubicin
drug binding
drug distribution
drug effect
Drug Interactions
drug potentiation
Drug Resistance
Drug Resistance,Multiple
drug transport
drug treatment failure
drug uptake
Enzymes
Epitopes
Fluorescence
Fluorescence correlation spectroscopy
Genes,MDR
glycoprotein P
histone deacetylase inhibitor
Hiv
Hiv-1
Homeostasis
Human
human cell
Humans
Hungary
Hydrolysis
Hydrophobicity
hydroxymethylglutaryl coenzyme A reductase inhibitor
In Vitro
Ivermectin
Kinetics
Light
lipid composition
lipid raft
Lipids
Membrane Microdomains
membrane permeability
Membrane Proteins
metabolism
methods
Mice
Microscopy
Models,Genetic
Molecular Biology
molecular interaction
monoclonal antibody
monoclonal antibody uic2
mouse
Multidrug resistance
Mutation
Neoplasms
nicardipine
nonhuman
Ovary
P-Glycoprotein
Paclitaxel
Peptides
Permeability
pharmacokinetics
pharmacology
Phospholipids
physiology
Proteins
Research
review
Rhodamine 123
Signal Transduction
Sphingosine
sphingosine 1 phosphate
Substrate Specificity
tariquidar
taxane derivative
Temperature
therapy
toxicity
trends
unclassified drug
Valinomycin
valspodar
Verapamil
Vinblastine
Vinca alkaloid
vincristine
Water
Xenopus
Megjelenés:Current Cancer Drug Targets. - 9 : 3 (2009), p. 281-297. -
További szerzők:Bacsó Zsolt (1963-) (biofizikus) Szabó Gábor (1953-) (biofizikus)
Internet cím:elektronikus változat
Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:
Rekordok letöltése1